Protein Info for DVU3278 in Desulfovibrio vulgaris Hildenborough JW710

Name: htrA
Annotation: peptidase/PDZ domain protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 518 transmembrane" amino acids 68 to 86 (19 residues), see Phobius details PF00089: Trypsin" amino acids 159 to 318 (160 residues), 61.5 bits, see alignment E=2.6e-20 PF13365: Trypsin_2" amino acids 160 to 297 (138 residues), 114.2 bits, see alignment E=2.2e-36 PF00595: PDZ" amino acids 335 to 388 (54 residues), 30.7 bits, see alignment 8.1e-11 PF13180: PDZ_2" amino acids 340 to 422 (83 residues), 35.7 bits, see alignment E=2.2e-12 amino acids 441 to 513 (73 residues), 35.2 bits, see alignment E=3.2e-12 PF17820: PDZ_6" amino acids 360 to 394 (35 residues), 34.9 bits, see alignment 2.5e-12 amino acids 452 to 506 (55 residues), 32.2 bits, see alignment 1.8e-11

Best Hits

KEGG orthology group: K01362, [EC: 3.4.21.-] (inferred from 100% identity to dvu:DVU3278)

Predicted SEED Role

"peptidase/PDZ domain protein"

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q725Z5 at UniProt or InterPro

Protein Sequence (518 amino acids)

>DVU3278 peptidase/PDZ domain protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPSPHMSSHDPASCSRPAGDSPPSCACPGASGPLPRTDWGVPAEGGVVSLPLRSVARRTG
RVASRRRAVLRVLCICLSCLCVLGGPDSQPVAFAAVDPASPRVTPVVQAVQRVAPAVVNI
TSARVEERRVNPMPGLLDDEMLDQLAPGLPKQRVTSRSLGSGVIIDGERRLVLTNAHVIA
GATSIAVRLLDGRTFTADLVGADPDFDLAVLRLAGAGRLPEAPMAHSADLMPGETVLAIG
NPFGFSHTVTTGVVSALNRTIRSKDGLFTDLIQTDAAINPGNSGGPLLNILGELIGINTA
VYARGEGIGFAIPIDKARGVVEELLGQGRVSPVWLGLSGQNVDPRTASVLGLGKVAGLLV
TEVFAGGPAATVGLEPGDVILSINGHDVGGKDEYLLLVGNYTHKDVLRVIIMRGGQEREL
RVVPAIFGRADAERLAAQRWGVILQQGRGGLVIAEVRPGSPAAQLGLARGDVLRAVGPRQ
VESLDDFAVAYRRYQLNAQVLIQVQRGARLYHVRLVLQ