Protein Info for DVU3246 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: RND efflux system, outer membrane protein, NodT family (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 signal peptide" amino acids 1 to 43 (43 residues), see Phobius details TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 34 to 497 (464 residues), 321.6 bits, see alignment E=4.4e-100 PF02321: OEP" amino acids 86 to 282 (197 residues), 74.8 bits, see alignment E=4e-25 amino acids 313 to 490 (178 residues), 70.6 bits, see alignment E=7.7e-24

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvu:DVU3246)

Predicted SEED Role

"RND efflux system, outer membrane lipoprotein CmeC" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q725M3 at UniProt or InterPro

Protein Sequence (541 amino acids)

>DVU3246 RND efflux system, outer membrane protein, NodT family (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPESPHRPHPDRSPSGRHSTFTRLLRACLTPVLLLTLLTACAKVGPDFSAPGGDVPDVWQ
DASHPVASSDADVDGTWWNTFNDPVLDSLVTEARSANLSLHLAALRVFEARARLGAAVGN
LYPQTQQGTGGLTWTHPSDRAPTAPQPTTGRDNPDYVQTSAGLDVAWELDFWGKFRRGIE
AADADLRASMADHQTALVSVSAEVARSYILYRTVQKQLAIAETNVAIQRESLRIATARFN
YGATSERDMRQALSLLRDTEARIPNLAHSLRETRNALCVLLGKAPQDISARLGDAPIPTA
PTHVAVGIPADLLRRRPDVHKALATAAGQCARLGVAKADFYPAFTLGGFVGFTASNVGAF
GLGDTFSNGFTAYGGPGLSLPLFNYGRIVSNVRAQDARFQQSLTSYRETVLVALRETEDA
IDRFIQAQGRTALLTESASDAARSMQLALIQYQEGSTDFTTVLTAARDLATREDALAAAK
GEICQSLVAMFKALGGGWHKLPGDVFIPVNALREMRERTHWGSLLEEDAPPASEGIRLPD
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