Protein Info for DVU3181 in Desulfovibrio vulgaris Hildenborough JW710

Name: purL
Annotation: phosphoribosylformylglycinamidine synthase II (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 993 PF18072: FGAR-AT_linker" amino acids 192 to 251 (60 residues), 57.5 bits, see alignment 3.1e-19 PF00586: AIRS" amino acids 301 to 425 (125 residues), 54.2 bits, see alignment E=3.6e-18 amino acids 681 to 793 (113 residues), 20.6 bits, see alignment E=1e-07 PF02769: AIRS_C" amino acids 440 to 588 (149 residues), 92.8 bits, see alignment E=5e-30 amino acids 825 to 969 (145 residues), 88.8 bits, see alignment E=9e-29

Best Hits

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 100% identity to dvl:Dvul_0206)

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, PurS subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.3

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q726B8 at UniProt or InterPro

Protein Sequence (993 amino acids)

>DVU3181 phosphoribosylformylglycinamidine synthase II (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MLRRIEVGLRPQVTDTVGRKVAAKIHESLGLDAGDVRLVKVFTIDGLDAAQLETVVREAV
LFDPVLQHASLDPLDSDADWVLEVGFRPGVTDNEGRTARDTLALVLGIADRRSIAVYTAN
QYHLHCGLDRAAVERIARDLLANELIQRYALKSREEWAASPGFPAQAAQVTGARNDEVAV
IPLLSMSDDELMAFSRANTLALSLEEMHAIRAYYQRDDVRAARAAEGLPADPTDAEVEAL
AQTWSEHCKHKIFSSRIDYENRETGRRETIDSLFKSCIQDTTKTIRARLGDKDFCRSVFK
DNAGVIAFNDTHDICIKVETHNSPSALDPYGGALTGIVGVNRDPMGTGMGANLVCNTDVF
CFASPFWEGELPPRLLHPRRVLEGVREGVEHGGNKSGIPTVNGSIVFEDRYLGKPLVYCG
TVGMIPAQVAGKPGYTKEARPGDAIVMVGGRIGKDGIHGATFSSEELHEGSPATAVQIGD
PITQRKMYDCIMRARDMGLYTAITDNGAGGLSSSVGEMAQDTGGCRLDLARAPLKYDGLR
PWEILLSEAQERMTLAVPQDKLEAFMRLASEMDVEATVLGEFTDSGYFHITFGDRQVAYL
DMDFLHDGVPQLQLKAVWERPAHPEGRIDLPEEEQGPFLRRMMGSLNICSKEYVIRQYDH
EVKGGSVVKPLVGVKRDGPADAAVVRPLLDSESGIVLSHGICPKFSDYDAYWMMANAIDE
AVRNAVAVGGDPDFMSGVDNFCWCDPVQSDKTPDGHYKLAQLVRANRALEHFCLAYGVPC
VSGKDSMKNDYTGGGTKISIPPTVLFSVMGVIDDVNRTVTSDFKRAGERIYLLGLTRREM
AGSEAAQVLGISCADVPQVDAPAALARYRALYGAIRAGLVTACHDLSDGGLAVALAEMCL
GGRLGARCDLARVPVCGDMTTTELLYSESASRLLVSVRPADADAFEAAFAGQHYACVGEV
TADGRLTLETKGTAIVSEEVEALATAFKATLDW