Protein Info for DVU3156 in Desulfovibrio vulgaris Hildenborough JW710

Name: glmS
Annotation: glucosamine--fructose-6-phosphate aminotransferase (isomerizing) (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 607 (606 residues), 760 bits, E=9.1e-233
• PF13522: GATase_6
  • amino acids 66 to 191 (126 residues), 72.4 bits, E=5.8e-24
• PF13537: GATase_7
  • amino acids 80 to 200 (121 residues), 55.7 bits, E=7.4e-19
• PF01380: SIS
  • amino acids 294 to 417 (124 residues), 116.1 bits, E=1.5e-37
  • amino acids 463 to 550 (88 residues), 56.7 bits, E=3.4e-19

Best Hits

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 100% identity to dvu:DVU3156)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Sequence Analysis Tools

See Q726F2 at UniProt or InterPro

Protein Sequence (607 amino acids)

>DVU3156 glucosamine--fructose-6-phosphate aminotransferase (isomerizing) (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MCGIIGYAGHRPAVPVVIEGLRRLEYRGYDSAGVAFVQNRELNTVRAEGKLAALEERLAG
CPNTVATTGMGHTRWATHGVPAERNAHPHKSNDGSLAIVHNGIIENYQELKNDLLAKGYV
FHSETDTEVLANLIAEGRKHTATTLDAFAWALRQAHGAYAVALTTPEEPDVLYAARLSAP
LILGVGTGENFVASDIPAFLPYTRDVVFLEDGELVRLDAHSWKVMRIADLSAVDKPVHHI
QWDMQAAQKGGYKHFMLKEIFEQPKVVTDCLAGRVDWAREEVTLPELAALPVPKRLHIVA
CGTSLHAGMWGKHLLESWAKVPVSVEIASEFRYRDILLDPEDMVLVISQSGETADTLAGL
RIAREKGVKVAGLCNVVGSSIAREADAVIYTQAGPEISVASTKAMCSQMVLLTLLALYWG
RRKATLADDVRHEALSALRKLPGQLESALPGMRDEAQQLARTYSKARSFFYLGRGHCFPL
ALEGALKLKEISYIHAEGYASGEMKHGPIALIDPEFPTFALALADDLFPKVKSNIEEVQA
RRGKVIALTNPGVEVRVDNPWVVPAAWGPLAAFIALPALQLFSYEAADYLGKDVDQPRNL
AKSVTVE