Protein Info for DVU3062 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: sensor histidine kinase/response regulator (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1080 transmembrane" amino acids 13 to 34 (22 residues), see Phobius details amino acids 159 to 183 (25 residues), see Phobius details PF00672: HAMP" amino acids 178 to 229 (52 residues), 36.4 bits, see alignment 1.3e-12 PF00512: HisKA" amino acids 266 to 330 (65 residues), 58.3 bits, see alignment 1.6e-19 PF02518: HATPase_c" amino acids 377 to 489 (113 residues), 104 bits, see alignment E=1.6e-33 PF00072: Response_reg" amino acids 699 to 810 (112 residues), 64.5 bits, see alignment E=2.4e-21 PF01627: Hpt" amino acids 990 to 1067 (78 residues), 31.1 bits, see alignment 5.6e-11

Best Hits

KEGG orthology group: K00936, [EC: 2.7.3.-] (inferred from 100% identity to dvu:DVU3062)

Predicted SEED Role

"sensor histidine kinase/response regulator"

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q726P4 at UniProt or InterPro

Protein Sequence (1080 amino acids)

>DVU3062 sensor histidine kinase/response regulator (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MPHSSRSAIGLQVRVSLLVLMVTMVLLAGFAFWEHTLLREAEEMQLRQETRLLADRAARL
LALPLWNLDGPSARAIIQAEMDDPRVYGIAVFEQGRQLFEGMQRDASWRVVPWVGSAPPD
VVEERRDLVVEGTQVGSLSIMVSPRFLAARLAERFQQAVWRYTLLAGILAVGLMLLVRSV
LIAPLGRLGGVARRVTSEENFALRAPKGADDEIGELVDSFNAMLERIEQRNRLLGEQRRR
LEMEVSERTAEFVGARERAERESKAMADFLAAITHEVRTPMTGIIGLLDISLRGQLEPRL
REHLEIVRSSSHALLDVINGVLDFSRIEAGKLRIERIPFALRESVEDVLDLFRAHLAERD
VALVLDMASDLPCKVAGDPTRLRQVLVNIVGNAFKFTEQGEIVVRISHERQGDGSVLLRF
AVRDTGVGIPAEARKRLFEMFSQADASVARRFGGSGLGLAIARELVRLMGGSIEVDSTPG
RGTVFRFTVHCGFVEGPSDPLPLPQGVRVVLGESHASLQRVLSGLLRRWGAEVVAVSGAA
ALKDAAADADVCVLSSHLQGGLAALSRPGQPGPPVLLLVPYGEEPEPSLCAGAGVVAFVG
RPVRAATLRAALDAVFAPGMPDGAQATAMKGDMRAGLHIPSSRDGSGGASSAARVVEGQA
VTGPMTQPGAMPSVGASGDGHDADQSVHEGGSGLEGMRVLVAEDDDVSRLVLREMLTGFG
VQVNETADGATMLAHFAAAPYDVVLIDVQMPVLDGFATLERLRALPDGDTVPVALFTAQK
LSVAELAERGIRVAGVVEKPLEMETLVAFLRGLRAVKGQGRHDVAGADAAPRMAGQEHGE
SAVTDATLSPNAATLISGETLVLGGTADGAATRGVGVPGMAAVAEVIASGGHETETSSST
SDANASSFESGAATPSSIPGDGASSHMPDAEASSVPAGVADVSAVAATTTSRSRAPRRLA
GPPLPTALEGVDIGEVLTRVGGKEWLLLKVLRSFVTAYADAADGLAAMVEAGDDEAVKLR
GHTLAGAAGNISAHELRAICLALEMGGDKSTQQSLVAAFRGELDRVVTSIREMLARYEEP