Protein Info for DVU2883 in Desulfovibrio vulgaris Hildenborough JW710

Name: selA
Annotation: L-seryl-tRNA selenium transferase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 469 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF12390: Se-cys_synth_N" amino acids 5 to 48 (44 residues), 28.3 bits, see alignment 1.6e-10 TIGR00474: L-seryl-tRNA(Sec) selenium transferase" amino acids 5 to 465 (461 residues), 630.9 bits, see alignment E=6.3e-194 PF03841: SelA" amino acids 86 to 451 (366 residues), 541.6 bits, see alignment E=9.8e-167

Best Hits

Swiss-Prot: 100% identical to SELA_DESVH: L-seryl-tRNA(Sec) selenium transferase (selA) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K01042, L-seryl-tRNA(Ser) seleniumtransferase [EC: 2.9.1.1] (inferred from 100% identity to dvl:Dvul_0482)

Predicted SEED Role

"L-seryl-tRNA(Sec) selenium transferase (EC 2.9.1.1)" in subsystem Selenocysteine metabolism (EC 2.9.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.9.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See P61735 at UniProt or InterPro

Protein Sequence (469 amino acids)

>DVU2883 L-seryl-tRNA selenium transferase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MNRLFRALPSVDALLTALTTPTHGHDTFADLPRALLRDLVNDFLDARREDIRQGRIDAPE
SLAAERLLPSLVQSVGRRSRAHFRRVLNGTGVVIHTNLGRSLLAPAATEAVAAACAHYSN
LEFDLDTGERGSRYSHVEQLLCRVTGAEAGLVVNNNAAAVLLVLDTLCKGGEVVVSRGQL
VEIGGSFRIPDVMEKSGATLREVGATNRTHLRDYENAINEKTVALLRVHTSNYRVVGFHK
EVPLDELVALGRARDLPVIEDLGSGSFLDFTPWGLPGEPTVQSVVGAGPDVITFSGDKVL
GGPQAGLIVGRRQWIDRIKRNPLNRALRIDKMTLAALEATLRLYLDPERARNEVPTLRMM
TASPDELARRARRLAARLRKALGDAARVGTVPGVSRVGGGSFPERDLPTTLVEVAPASCT
ATVLKTRLLDTDPPLVGRLENDTFRLDPRTLDDVEFAPVATALRQALGL