Protein Info for DVU2757 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: radical SAM domain protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 375 TIGR03699: dehypoxanthine futalosine cyclase" amino acids 31 to 366 (336 residues), 516.7 bits, see alignment E=2.2e-159 TIGR00423: radical SAM domain protein, CofH subfamily" amino acids 66 to 365 (300 residues), 379.2 bits, see alignment E=1.5e-117 PF04055: Radical_SAM" amino acids 74 to 245 (172 residues), 60.9 bits, see alignment E=1.8e-20 PF19288: CofH_C" amino acids 257 to 366 (110 residues), 128.4 bits, see alignment E=1.5e-41

Best Hits

Swiss-Prot: 47% identical to MQNC_BACHD: Cyclic dehypoxanthine futalosine synthase (mqnC) from Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)

KEGG orthology group: None (inferred from 100% identity to dvl:Dvul_0550)

MetaCyc: 49% identical to dehypoxanthinylfutalosine cyclase (Campylobacter jejuni)
RXN-10620 [EC: 1.21.98.1]

Predicted SEED Role

"Menaquinone via futalosine step 3" in subsystem Menaquinone Biosynthesis via Futalosine

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.21.98.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q727U7 at UniProt or InterPro

Protein Sequence (375 amino acids)

>DVU2757 radical SAM domain protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MSQHPVAGTQSPFMEADAVRTIAAHVLSGGRIDRAGAETLYHEASLHTLAHLAHAVRLRR
HPEPVVTYVADRNINYSNICVCACRFCAFYRAPGAEGGYVLSREELARKIDETLVLGGTQ
ILLQGGHHPDLPLHFYEDMIGWIRATYPAIHIHAFSPPEIVFFAEKEHLTIGEVIERLRA
AGLDSIPGGGAEILVDEVRTKVSPNKCSAELWLAVMEEAHYQGLRTTATMMFGHEETHAH
RLDHLFAVRDVQDRTGGFTAFIPWTFQPANTAIDRDPEPAPAYLRLLALSRIVLDNIDNI
QASWVTMGPHVAQLALFYGANDFGSLMIEENVVAAAGVSFSLSRGEIHKIIRAAGFTPVQ
RTMDYTPVVPQPVEA