Protein Info for DVU2559 in Desulfovibrio vulgaris Hildenborough JW710

Name: bioA
Annotation: adenosylmethionine--8-amino-7-oxononanoate aminotransferase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00508: adenosylmethionine-8-amino-7-oxononanoate transaminase
  • amino acids 69 to 499 (431 residues), 533.9 bits, E=1.1e-164
• PF00202: Aminotran_3
  • amino acids 84 to 496 (413 residues), 338.2 bits, E=2.9e-105

Best Hits

Swiss-Prot: 100% identical to BIOA_DESVH: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K00833, adenosylmethionine-8-amino-7-oxononanoate aminotransferase [EC: 2.6.1.62] (inferred from 100% identity to dvu:DVU2559)

MetaCyc: 49% identical to lysine-8-amino-7-oxononanoate aminotransferase (Bacillus subtilis)
RXN-14930 [EC: 2.6.1.105]

Predicted SEED Role

"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)

MetaCyc Pathways

• biotin biosynthesis I (13/15 steps found)
• biotin biosynthesis from 8-amino-7-oxononanoate I (4/4 steps found)
• biotin biosynthesis from 8-amino-7-oxononanoate II (4/4 steps found)
• biotin biosynthesis II (5/6 steps found)

KEGG Metabolic Maps

• Biotin metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.105 or 2.6.1.62

Sequence Analysis Tools

See Q728P4 at UniProt or InterPro

Protein Sequence (542 amino acids)

>DVU2559 adenosylmethionine--8-amino-7-oxononanoate aminotransferase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MSTSPFNSRVAPMPHDDATAPVLHYAHDAAGAHDAADAAGAHDAADAAGTPPCAASRTAR
LRSLDAAHVWHPFTQMRDWMGSEPCIIDAADGNHLIDTDGNRYLDGVSSLWTNVHGHRHP
HIDEAIRRQLDRVAHSTLLGLGGTPSIELAARLTAIAPAGLTRVFYSDSGSTAVEAALKI
AFQYHRQAPEGDARRTRVMAFSNAYHGDTIGSVSLGGMSLFHGIYGPLLFDPVRAPAPHC
YRCPADLRPETCGMACLGEVERLMRHHGHELCAVVVEPLVQGAAGMLVQPRGWLRGLRDL
CDRHGVFMVADEVAVGFGKTGTMFACEQEGVVPDMLCLAKGITGGYLPLAATLVTEHIHD
GFLGGYADFRTFFHGHTYTGNALACAAALASLDVFEEERTLETLRPRIERLATLLAPLND
LPHVGDIRRVGVMTGIELVADRETRTPYRPEERIGHRVTLEARRRGVIVRPLGDVMVLMP
PLSITETELETLVHTVRGAIIAVTEHGADGGLWTKRPDGPDNPDKANTPDTPDGARTGET
VV