Protein Info for DVU2557 in Desulfovibrio vulgaris Hildenborough JW710

Name: birA
Annotation: birA bifunctional protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 330 PF13412: HTH_24" amino acids 7 to 53 (47 residues), 26.6 bits, see alignment 1e-09 PF01022: HTH_5" amino acids 9 to 54 (46 residues), 27.6 bits, see alignment 6.3e-10 PF08279: HTH_11" amino acids 10 to 63 (54 residues), 50 bits, see alignment 6.7e-17 TIGR00121: biotin--[acetyl-CoA-carboxylase] ligase" amino acids 91 to 327 (237 residues), 167.9 bits, see alignment E=1.4e-53 PF03099: BPL_LplA_LipB" amino acids 94 to 217 (124 residues), 64.6 bits, see alignment E=2.8e-21 PF02237: BPL_C" amino acids 282 to 326 (45 residues), 21.1 bits, see alignment 7.3e-08

Best Hits

KEGG orthology group: K03524, BirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC: 6.3.4.15] (inferred from 99% identity to dvl:Dvul_0691)

Predicted SEED Role

"Biotin operon repressor / Biotin-protein ligase (EC 6.3.4.15)" in subsystem Biotin biosynthesis (EC 6.3.4.15)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.15

Use Curated BLAST to search for 6.3.4.15

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q728P6 at UniProt or InterPro

Protein Sequence (330 amino acids)

>DVU2557 birA bifunctional protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MDDRGRNGTRRRVLERLFEADGWCSGEELSRELGVSRAAVGKHVRALRAAGYVIEAVTRR
GYRLDRTTAPFEAAEVLRGLATEVFGKVGLHWHESTDSTNRDAVALAVGGACEGTVVMAA
QQLAGRGRTGRPWVSPQGGVYVSLVLRPRLSPQAAPLVTLMTAVAAAEAVEAVTGLMPEV
KWPNDLLMAGLKVCGNLTEVGLVADMVDWVVTGVGVNVSTPAEALVDAGVAATSLQTECG
RPVARADVARAFLERAEHWYGALREGDTGAVITRWKELSDIVGRHLRVRHGDELVEGRVA
DMTPEGWLCILAGNGTLHRLHAGDVIDSRV