Protein Info for DVU2538 in Desulfovibrio vulgaris Hildenborough JW710

Name: thrS
Annotation: threonyl-tRNA synthetase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 644 TIGR00418: threonine--tRNA ligase" amino acids 72 to 629 (558 residues), 725.1 bits, see alignment E=3.8e-222 PF07973: tRNA_SAD" amino acids 168 to 217 (50 residues), 56 bits, see alignment 4.9e-19 PF00587: tRNA-synt_2b" amino acids 318 to 527 (210 residues), 163.3 bits, see alignment E=9.9e-52 PF03129: HGTP_anticodon" amino acids 539 to 627 (89 residues), 68.4 bits, see alignment E=7.2e-23

Best Hits

Swiss-Prot: 100% identical to SYT_DESVH: Threonine--tRNA ligase (thrS) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K01868, threonyl-tRNA synthetase [EC: 6.1.1.3] (inferred from 100% identity to dvl:Dvul_0707)

Predicted SEED Role

"Threonyl-tRNA synthetase (EC 6.1.1.3)" (EC 6.1.1.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q728R5 at UniProt or InterPro

Protein Sequence (644 amino acids)

>DVU2538 threonyl-tRNA synthetase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MNVSIEGQMLEVASGASCGDALKGALSGKKFKNVLACRLDGGLVDITATVPDGTTTIEPV
YADSPEGLDLIRHSTAHIMACAVKRLFPAAKVTIGPSIDNGFYYDFDAERPFSPEDFEAI
EREMQKIVDAATPFERSEMPRDEAVALFEGMGETYKVEIIRDLPNDTVSLYRCGEFVDLC
RGPHIPHAGFAKAFKLMSVAGAYWRGDEKNPMLSRIYGTAFADAKTLKEHLHRIEEAKRR
DHRKLGQQLDLFAFHEDVAPGMVFWHPKGMLVRTIIEDFLRKEHLKRRYDIVQGPQLLRR
ELWEKSGHYDNYRENMYFTEIDENAYGVKPMNCLAHMLIYRSAIRSYRDLPKRFFELGVV
HRHEKSGVLHGLLRVRQFTQDDAHIICRPDQLEDEIIDVIALVRDLMNLFGFDYKVAVST
RPEKSIGSDEAWELATNALVKAVERAGIPYTINEGDGAFYGPKIDVRLMDCIGREWQCST
IQCDFTLPERFDLVYVGQDGERHRPVMVHRAILGSLERFIGVLIEQYAGAFPAWLAPVQA
RLLTVTDAQNEFVESARAALAKAGIRVEADVRNEKLGYKVREAQLEKIPYILVVGDKEVE
AGGVNVRLRTGENLGLKSLDEVVSLLESDCQEPFKRGGMSYSFS