Protein Info for DVU2432 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: sensory box/GGDEF domain/EAL domain protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1413 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 261 to 282 (22 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 411 to 534 (124 residues), 39.2 bits, see alignment E=7.1e-14 amino acids 540 to 583 (44 residues), 26 bits, see alignment (E = 8.3e-10) amino acids 677 to 802 (126 residues), 26.9 bits, see alignment E=4.5e-10 PF13426: PAS_9" amino acids 421 to 526 (106 residues), 23.4 bits, see alignment 3.3e-08 amino acids 549 to 667 (119 residues), 20.9 bits, see alignment E=2e-07 PF00989: PAS" amino acids 544 to 582 (39 residues), 27.7 bits, see alignment (E = 1.3e-09) PF08448: PAS_4" amino acids 549 to 669 (121 residues), 44.4 bits, see alignment E=9.9e-15 PF08447: PAS_3" amino acids 703 to 791 (89 residues), 43.6 bits, see alignment 1.6e-14 PF13185: GAF_2" amino acids 819 to 957 (139 residues), 52.6 bits, see alignment E=3.3e-17 PF01590: GAF" amino acids 820 to 956 (137 residues), 46.5 bits, see alignment E=2.9e-15 PF13492: GAF_3" amino acids 821 to 958 (138 residues), 38.7 bits, see alignment E=7.1e-13 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 967 to 1130 (164 residues), 137.7 bits, see alignment E=3.1e-44 PF00990: GGDEF" amino acids 969 to 1126 (158 residues), 156.5 bits, see alignment E=2.9e-49 PF00563: EAL" amino acids 1147 to 1386 (240 residues), 253 bits, see alignment E=1.4e-78

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvu:DVU2432)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q729B9 at UniProt or InterPro

Protein Sequence (1413 amino acids)

>DVU2432 sensory box/GGDEF domain/EAL domain protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MSRYIRALLCCVVIALIVAGASPIRASDVGSLPLRLALRPDMPPYQFFDMEGRPQGLVVT
VWESWTRATGTPVIFVPVTENEIPDAFARSRIDAVAALPAQLLPRFGLAEAAEVGHLSVG
IFSHTGNSSPDPADQGQGSVTSPAIPAGMGLATILQDTLPGVNPVVFPDTTSLLAAAHAG
NVRQIALYMAHGDYLRKHGRLEGFDAGIAVASSRLVAALPAADIARKQRIRLGFSRLADT
DHRDLEAMWHGAQTAFPFMRPLVLLGVLTFLLLVVVLGRNLALRRRMEKERAERRRTENM
LDGFLERLPDNHFTLDVDGTGAVVMASNGTEDVLGVSPDEAPSRLRHLLPPTKDGAWSQA
SFSIEAAHADGSLRTLDCLATTPDERGHRRVLVFDTTRRNLERQRVEAIHHRYMSILDNA
PVGIFRIMPDGSMVGANREMARLWGFSSPEELLASEEARRLILCDDPKACPLSFARIAAS
GGLVNEEVLCRTRDGRSFTGLVSARAVPQDDDVQSYVDGFLLDISQLKEARDKLRQTSRN
LADIIDFYPDATLVVDAAGRLVAWNRAMEELTGIAAADMIGKGDYEYALPFYGERIPILC
DLLRDPAIIPAARYSLLEQTEHRIVVELPLPFFRKGRGLFVWTAASALTDEHGKVTAVIQ
VIRDVTERRIELEALAKSRERYQMAIEATNEGIWEWDVTTGELYHSPRCVEILGRGGASA
PDTLLRDLSLQVHPDDRLRMVTLTQSLMTEPVERFSLECRMRHPVQGWRWVLCHGVVQRN
GSGGPRRITGSIADITERKQSEIISAILLQISNAVNVTHDIEGLFSTIHDILRSYVAAEN
FFIALVDEKQDRLEFPYHTDEKDPSLPRLESISSLASPPPTLEVIRTGRQLLLSYEDLLG
RAYIGTIASVWLGTPLRVRGKVIGAMVLQHYSDPDAFSDSDARLMTSLADQIAVAIERKQ
NEEQLTYLALHDSLTGLPNRTLLLERIEQARLRSLRGKGRSFAVMMIDLDRFKIINDSHG
HAVGDRLLQMVSAAVRPVLRPADTVARLGGDEFAILLEDVATPREVVHVARRVIKAVERP
ARVANKLLRTSASVGIVLRTDGYGSADELLRDADIAMYQAKEQGRGRFRVFNRTMHQQAM
DAMNLENDLGAALRWGQFELDYQPVFDTRSRALLGFEALVRWRHPLRGLIPPTAFIPVAE
ETGIITRLGHWVLETALTALARWRLQIPGIDDLYVAVNMSALQFAQPTLPGSVRDALQKT
GLPASCLKVEITETAIMQDPTTALQRISALRDLGVGIGIDDFGTGYSSLAYLQRFPVDTL
KVDRSFVSQSTTPEGEGNREIVRAVVVLAHSLSLAVVAEGVETEEQFAFLAGLGCDAVQG
YLLSRPVPEADIPAHISTTWALPAQGDAIPESP