Protein Info for DVU2324 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: copper-translocating P-type ATPase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 905 transmembrane" amino acids 189 to 209 (21 residues), see Phobius details amino acids 220 to 239 (20 residues), see Phobius details amino acids 259 to 280 (22 residues), see Phobius details amino acids 292 to 310 (19 residues), see Phobius details amino acids 460 to 482 (23 residues), see Phobius details amino acids 489 to 510 (22 residues), see Phobius details amino acids 845 to 866 (22 residues), see Phobius details amino acids 872 to 892 (21 residues), see Phobius details TIGR00003: copper ion binding protein" amino acids 13 to 74 (62 residues), 45.3 bits, see alignment 1.9e-15 amino acids 89 to 129 (41 residues), 37.9 bits, see alignment (E = 4.1e-13) PF00403: HMA" amino acids 15 to 73 (59 residues), 50.7 bits, see alignment 3.9e-17 amino acids 90 to 152 (63 residues), 49.2 bits, see alignment 1.1e-16 PF00122: E1-E2_ATPase" amino acids 356 to 523 (168 residues), 180.3 bits, see alignment E=5.5e-57 TIGR01494: HAD ATPase, P-type, family IC" amino acids 357 to 564 (208 residues), 139.2 bits, see alignment E=3.6e-44 amino acids 685 to 864 (180 residues), 157.6 bits, see alignment E=9.6e-50 PF00702: Hydrolase" amino acids 540 to 799 (260 residues), 123 bits, see alignment E=4.2e-39

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to dvu:DVU2324)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q729M6 at UniProt or InterPro

Protein Sequence (905 amino acids)

>DVU2324 copper-translocating P-type ATPase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MDSQTDSVRHRSRMPVRGMTCAVCAGRIEKMVGRMEGVETVAVNLATEVMDVTWDDRTDL
DAIVRQVSALGFEAMPPDAAPAGGGNDLRFAVSGMTCAVCAGRIEKVVGTMDGVGAVSVN
LAAETAQVTPLPGVDAGSLAASVVERISGLGFGATLQEQAADAASSASLWERQRHDADAR
LARMKARLVPEFGFTVPLLLLSMGHMMGLPLPGFLHPAHSPLTFAVAQLLLTLPVMWSGR
DFYRIGFGNLRRLSPNMDSLVALGTGAAFIYSLWNTVEIALGVDVAHRVMDLYYESAAVL
ITLVSLGKYFEMRSRARTSEAIKSLMDLAPETALRLVSADGGPAVGHEAGDGTNVAVQEV
PVAEVRAGDLLQVRPGARIPVDGTVVSGTSSVDESMLTGESLPVSKTGGDSVAGGTINRL
GTFVMRAERVGADTVLARIIRLVEEAQGSKAPIANIADRVSLYFVPTVMALAVLAGVGWY
TVGDADFTFALRIFVAVMVIACPCAMGLATPTSIMVGTGRGAQLGILVKSGAALETAGRV
DTVVFDKTGTLTEGKPRLVHVSAVEDGPWQTDVSASGGDGTQGGASGMRLTQPLAPDVAE
DTPRRMVLRLAASLEAVSEHPLAEAILAGAAEAGIAPWPVEAFEAVPGRGVRGRVRTDAG
ESGVLLGNHAFMAEAGVAGLDAHGLREMLDALADAGVTPLLLAAAGEMRGIVGVADPLRA
EARGVLERLRQCGVRAVMLTGDNRRTAEAIARQAGMDEVVAEVMPDAKEREVSRLQGEGR
VVAMVGDGINDAPALARADVGIAMGTGIDVAVEAGDIVLLRGGLTSVPVAMQLSRATMRN
IRQNLFWAFGYNVLGIPVAAGLLYAFGGPTLSPMLAGAAMALSSVSVVGNALRLRLFTPE
RGGTC