Protein Info for DVU2302 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: glutathione-regulated potassium-efflux system protein KefB, putative (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 672 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 51 (22 residues), see Phobius details amino acids 57 to 74 (18 residues), see Phobius details amino acids 86 to 109 (24 residues), see Phobius details amino acids 115 to 135 (21 residues), see Phobius details amino acids 147 to 170 (24 residues), see Phobius details amino acids 180 to 202 (23 residues), see Phobius details amino acids 217 to 251 (35 residues), see Phobius details amino acids 270 to 289 (20 residues), see Phobius details amino acids 295 to 319 (25 residues), see Phobius details amino acids 325 to 346 (22 residues), see Phobius details amino acids 356 to 380 (25 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 15 to 373 (359 residues), 193.5 bits, see alignment E=8.2e-61 PF02254: TrkA_N" amino acids 407 to 518 (112 residues), 67 bits, see alignment E=2.8e-22 PF02080: TrkA_C" amino acids 581 to 650 (70 residues), 53.5 bits, see alignment E=2.7e-18

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 100% identity to dvu:DVU2302)

Predicted SEED Role

"putative Glutathione-regulated potassium-efflux system protein KefB" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q729P8 at UniProt or InterPro

Protein Sequence (672 amino acids)

>DVU2302 glutathione-regulated potassium-efflux system protein KefB, putative (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MQLPLLPDIVVLFCLSIGVLLVCHRVRLPAIVGFLITGVLCGPSALGLVSAVHEVELMAE
IGVVLLMFTIGMELSGDELSRLRKPVFIGGTAQVGLTVAVFAGIALLHGQTLSEGILFGF
LAALSSTAIVLSLLQQRAQTESPQGRIALSVLIFQDIAIVPMMLAIPLLAGTITADAKSL
ALSVGRTVAVLGGLVLLARYVVPPLMERVVRTRSRELLLLTTLGLCLAVALLTSSMGLSL
SLGAFLAGLLLAESEYSLSVIEGVLPFRDVFTSLFFISVGMLLDVGFLFDNLGAVLAVAA
ALVVLKAAIATPAILLLGYPLRTCIIAALALAQIGEFSFVLARSGLEHGLLGKDAYQMFL
AASIITMTLTPGLLAVAPRFARYVSTLLKSHETFDEAHGAALHDHLIVVGFGVGGKHLAR
VAREAGIAYTILEMNPDTVARYHGKEPIHHGDATHPLVLEHLGVRQARILAVVISDPAAV
RGVTAAARALNPALHIVVRTRFLGEVTALRDLGANEVVPEEFETSIEVFSRVLTHYLVPR
QTIDGFIDRIRAENYDMLRSHDLPGSTLAALEGGLPGVAVEAYTVEAGASIAGRTLLESD
LRQRHGVTVVAIRRGETTLASPDGSMALLPGDVAYVFGEPTALHDAAALFSKATGDAPFA
ERVPSSVSETAA