Protein Info for DVU2225 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: acetyl-CoA carboxylase, carboxyl transferase, alpha/beta subunit (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: K01962, acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC: 6.4.1.2] K01963, acetyl-CoA carboxylase carboxyl transferase subunit beta [EC: 6.4.1.2] (inferred from 100% identity to dvl:Dvul_1016)

Predicted SEED Role

No annotation

MetaCyc Pathways

fatty acid biosynthesis initiation (type I) (1/3 steps found)
jadomycin biosynthesis (3/9 steps found)
superpathway of mycolate biosynthesis (18/239 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.4.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q729X2 at UniProt or InterPro

Protein Sequence (751 amino acids)

>DVU2225 acetyl-CoA carboxylase, carboxyl transferase, alpha/beta subunit (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MDNEKRVQHLVERLGYIRDIFGGKHNENIELLATRLAEFSQRDTGAQGENGPALATLEDL
FTFVERKLEAELTPMDKVRIVRHAQRICLRDILENVYDNFTEIGGKDEYSIDPSMLIARA
YITRRSGKKTYHQPVMVIGQEKGHGEEFRNGGSVKPWGNAKALHYMKVAETEGIPIHTYV
FTPGSFPVEDYPGAAQQIARNLYEMAGLRVPVIAVFSEGGSGGAEAIGLADRRLMLSHGY
YSVISPEGGAAIEGRLRHGQRATPELIEKCAQQLRITAADNLRSGYIDHVIDEPPLGARP
YHFDFFRTLRQEVIRATDEVLLGVKGFAPLRAMALRRRRKTADLDLDSVYVRWSLSSSAK
DRLVARRQRKFLRLARAACKDRRPVMRKAASMWWDMWWDVYSTFKYDLFRKHQQKIAYVL
EEVDAEMQVLKEKVLKPWRRITCALPGSGGACEDTARDLTTLSEWDETEQRNGNWSYVSP
RAKQDRAITCPNAATHGCLDLWAPDLFGEFAGVCTSCGHHFPMEYQWYLHNVFDEGSVFE
FNAEVEAANPLSFEGFDVKLDQAKQKTGLKSGCVTFEARIDNTKVVVAMLVADFRGGSVG
AAEGEKFIQAAERAKKKRYPFLAYVHGTAGIRIQEGTNGVIQMPRCTIAVRRYIEAGGLY
LVLYDTNSYAGPVASFLGCSPYQFAVRSSNIGFAGPGVIKETTGMDIPPDYHRAYRALSR
GHIQGIWDRRDIRANVKQALLTMGGRNLYYR