Protein Info for DVU2129 in Desulfovibrio vulgaris Hildenborough JW710

Name: cckA
Annotation: sensory box histidine kinase/response regulator (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 823 TIGR00229: PAS domain S-box protein" amino acids 187 to 306 (120 residues), 25.7 bits, see alignment E=5.3e-10 amino acids 315 to 434 (120 residues), 27.7 bits, see alignment E=1.2e-10 PF13188: PAS_8" amino acids 188 to 231 (44 residues), 16 bits, see alignment 3.4e-06 amino acids 317 to 362 (46 residues), 20.5 bits, see alignment 1.2e-07 PF13426: PAS_9" amino acids 206 to 299 (94 residues), 20.2 bits, see alignment E=2.1e-07 amino acids 326 to 425 (100 residues), 31.4 bits, see alignment E=6.8e-11 PF08448: PAS_4" amino acids 320 to 429 (110 residues), 38.7 bits, see alignment E=3.7e-13 PF00512: HisKA" amino acids 444 to 507 (64 residues), 37 bits, see alignment 1e-12 PF02518: HATPase_c" amino acids 549 to 670 (122 residues), 76.7 bits, see alignment E=6.7e-25 PF00072: Response_reg" amino acids 692 to 803 (112 residues), 57.2 bits, see alignment E=6.4e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvu:DVU2129)

Predicted SEED Role

"FOG: PAS/PAC domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72A68 at UniProt or InterPro

Protein Sequence (823 amino acids)

>DVU2129 sensory box histidine kinase/response regulator (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MTANARDARRRNRSATGRNSSGSPGGAQAVVPAAAPPRHAHAGTEPARATTMSLLAVAPE
EDIHALARTLHHAGIAAAYTLATTPHTLSSALIDEPWDMVLVRPGLPGLSPTDALHLARA
ARSDLQCVALLHREETESAMALLKGGMDDVVVADDPILPAHMTRLAREAARRREHSRLWR
DMRHDVQQWRGMVDNTLLGIFRCQPWGDLVHANAAFAHILGHDDPAALVQQLRTENRSFL
DKNRMEHFLSRLSERDCIDDFEADLHKVDGTLTRVMLHARIIRDDNGEALSIEGTMEDIE
RRKSFEAVIINAKQEWEKTFDSVPDVIIIFSPELRIRRCNKALGRLLGLHPRDLVGRRCE
EVLGSGSSPNDACALLRSQESAGFSTGELHLPFLGGDFLVTLSPLQTGQNDEPAGDIVMV
AHDISNRKRLESQLRQAQKMEAIGTLAGGIAHDFNNILGVMMGYTEMSLDQADEDSPMHR
RLSEVLEAGKRARDIIHQILTMSRQEEPSRQMLSLSSPVRETLRLLRATLPANVDIRVDI
EDTAPVLANQSQIQQVVMNLCTNAAHAMRAKGGVLTVALDAVDLSAEEAQQRSLEGPATF
ARLRVRDTGHGIPSEIRENIFDPFFTTKKPDEGTGMGLALVHGIVTGHGGHVSFTSTAGF
GTEFEILLPVVSGHATKAEGDPDNLPKGGGEVLVVDDEASLALVMGEMLESMGYRADIAT
SPFEALERFSESPSRWAFVVTDQTMPGMTGMELAAHMLGVASSIRVILCTGFSEGLTEEA
AHKAGIARLLYKPVLRADMAEAVMGLAVSAGQGESSEAPVTVA