Protein Info for DVU2098 in Desulfovibrio vulgaris Hildenborough JW710

Name: cooS
Annotation: carbon monoxide dehydrogenase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 629 TIGR01702: carbon-monoxide dehydrogenase, catalytic subunit" amino acids 14 to 627 (614 residues), 691.5 bits, see alignment E=4.4e-212 PF03063: Prismane" amino acids 50 to 607 (558 residues), 598.5 bits, see alignment E=5.4e-184

Best Hits

Swiss-Prot: 53% identical to COOS1_METAC: Carbon monoxide dehydrogenase 1 (cooS1) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

KEGG orthology group: K00198, carbon-monoxide dehydrogenase catalytic subunit [EC: 1.2.99.2] (inferred from 100% identity to dvu:DVU2098)

Predicted SEED Role

"Carbon monoxide dehydrogenase CooS subunit (EC 1.2.99.2)" in subsystem Carbon monoxide induced hydrogenase (EC 1.2.99.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72A99 at UniProt or InterPro

Protein Sequence (629 amino acids)

>DVU2098 carbon monoxide dehydrogenase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MSSSKTIRSRSIWDDAHAMLEKAKAEGISTVWDRAAEQTPACKFCELGTTCRNCIMGPCR
IANRKDGKMRLGVCGADADVIVARNFGRFIAGGAAGHSDHGRDLIETLEAVAEGKAPGYT
IRDVAKLRRIAAELGVADAATRPAHDVAADLVTICYNDFGSRRNALAFLARAPQVRRDLW
QRLGMTPRGVDREIAEMMHRTHMGCDNDHTSLLVHAARTALADGWGGSMIGTELSDILFG
TPRPRQSTVNLGVLRKDAVNILVHGHNPVVSEMILAATREPAVRQAAQDAGAADINVAGL
CCTGNELLMRQGIPMAGNHLMTELAIVTGAADAIVADYQCIMPSLVQIAACYHTRFVTTS
PKGRFTGATHVEVHPHNAQERCREIVMLAIDAYTRRDPARVDIPSQPVSIMSGFSNEAIL
EALGGTPKPLIDAVVAGQIRGFVGIVGCNNPKIRQDSANVTLTRELIRRDIMVLATGCVT
TAAGKAGLLVPEAASKAGEGLAAVCRSLGVPPVLHMGSCVDNSRILQLCALLATTLGVDI
SDLPVGASSPEWYSEKAAAIAMYAVASGIPTHLGLPPNILGSENVTAMALHGLQDVVGAA
FMVEPDPVKAADMLEAHIVARRARLGLTS