Protein Info for DVU1903 in Desulfovibrio vulgaris Hildenborough JW710

Name: mfd
Annotation: transcription-repair coupling factor (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1160 PF17757: UvrB_inter" amino acids 140 to 226 (87 residues), 76.6 bits, see alignment 3.8e-25 TIGR00580: transcription-repair coupling factor" amino acids 158 to 1083 (926 residues), 977.3 bits, see alignment E=4.8e-298 PF02559: CarD_TRCF_RID" amino acids 489 to 544 (56 residues), 61.2 bits, see alignment 2.5e-20 PF04851: ResIII" amino acids 613 to 770 (158 residues), 32.3 bits, see alignment E=2.7e-11 PF00270: DEAD" amino acids 614 to 775 (162 residues), 87.2 bits, see alignment E=3.3e-28 PF00271: Helicase_C" amino acids 810 to 918 (109 residues), 60.8 bits, see alignment E=4.3e-20 PF03461: TRCF" amino acids 1014 to 1101 (88 residues), 68 bits, see alignment 2.3e-22

Best Hits

KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 100% identity to dvu:DVU1903)

Predicted SEED Role

"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72AT7 at UniProt or InterPro

Protein Sequence (1160 amino acids)

>DVU1903 transcription-repair coupling factor (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MLDFAALVRKLASKGCGHIEVTRSGMATAARLGNAVLDAGRSAVMVVRDAEELALARGLL
TLFSPDASAGDSPLVKPRWESRWVVMPQHPLGARNRDAWASRMAALFALGQKRVPQGVLI
TVDNFLSKLPPADLFASHELTLACGDEMAPELVLEQAVDWGFDRVQMVSRPGEIAVRGDI
VDIYPPGYERPLRLEFFGETLEEIRLFDASNQRSLGKLDEMVLLPVSPVVLSAELRSKAT
ARWKRLFSKGMLTEEQYAGLLRGIERHGEGLMPGAYYEAPTVVEEWLPRDAAWILPGRKE
LVDAVEAAQQNWEALFDKQAEEGGARQPRGLVLRDAAPVRQLYEEKDSAGFEPLVMGVER
TGVDMPERKLHGFVDLFPAPDARDRPWQALVAGLHRFVATHARVLLCFGNERGRRKFLKL
AEQDGITPTLRYDPKGRGLMAVVAPYRAGVELAWDGTLVIGEDVLQPKTDRSARVASGAF
RGLDKHEGLQPGDLLVHRDYGVARFVGLERMDLGGVGNDFLLLEYAGDDRLYLPVDRLSL
VQRFKGADDTKPSLDRLGGGAWQSSKDKARKAIEKIAADLVEMYAYRKIAKGYTYGPIGE
LYREFEASFGFEETPDQARAIQDVLEDMDKPVPMDRLVCGDVGFGKTEVALRAAFRAASE
GRQVALLCPTTVLAEQHYQTFRSRLAGFPVNVGMLSRFVSKQKQTEVLAAAAKGHVDILI
GTHRLLSDDVRLPNLGLLVLDEEQRFGVRHKEKLKQFRRNVDALTLTATPIPRTLQLSMS
GIRELSVIETAPPERKPVATALIERDDAALKSILEREIAREGQVFWVHNRVQGLERTTEY
VRKLVPDARVGMAHGQMTERALEETMHRFWHGELDVLVCTAIVESGLDFPRANTLIVDQA
QMFGLGQLYQLRGRVGRSDRQAYAIFVVPDADNLSDIARERMRVILDMDYLGAGFQVAME
DLRIRGAGNILGEAQSGHMTRVGLELFLEMLEEAVTRLKGDPPRESVETELNIGIPAHIP
EGYIEDARDRLRFYKALSSATDAAAQQDIEMEMRDRYGVFPPELETFLALLVLKRQLRRM
QVQRADIYPDKVRLVWDERQTAVDIGRLIEWVGQHADRARLQPPATLEWRLDTGLAAGAR
LDAMRGELFRLVPDSTPSSA