Protein Info for DVU1868 in Desulfovibrio vulgaris Hildenborough JW710

Name: dapA
Annotation: dihydrodipicolinate synthase (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to DAPA_DESVV: 4-hydroxy-tetrahydrodipicolinate synthase (dapA) from Desulfovibrio vulgaris subsp. vulgaris (strain DP4)

KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 100% identity to dvu:DVU1868)

MetaCyc: 46% identical to 4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli K-12 substr. MG1655)
DIHYDRODIPICSYN-RXN [EC: 4.3.3.7]

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)

MetaCyc Pathways

superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
aspartate superpathway (20/25 steps found)
L-lysine biosynthesis VI (7/7 steps found)
L-lysine biosynthesis III (6/7 steps found)
L-lysine biosynthesis I (7/9 steps found)
dipicolinate biosynthesis (3/4 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (13/18 steps found)
L-lysine biosynthesis II (6/9 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.52 or 4.3.3.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72AX2 at UniProt or InterPro

Protein Sequence (292 amino acids)

>DVU1868 dihydrodipicolinate synthase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MQFTGAFTAIVTPFRNGRVDEERFRELIEWQIEQGINGLVPCGTTGESATLSHDEHRDVI
RICVEQVKGRIPVLAGAGSNNTREAIDLTRFAKEAGADGALLITPYYNKPTQEGLYLHFK
AIASEVSMPFIVYNVPSRTGTNICPETLARLNRDIPEVVGVKEATGNLIQVSEILEYCGT
DFQVLSGDDFTVLPLLSVGGCGVISVTSNVVPAKMSDMCRAFKAGDLATARRLHFELSPI
NRAMFLETNPIPVKTALALMGRIDLEMRLPLCPLQQVNQSRLRDILAAAGIL