Protein Info for DVU1834 in Desulfovibrio vulgaris Hildenborough JW710

Name: pyc
Annotation: pyruvate carboxylase, putative (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1234 PF00289: Biotin_carb_N" amino acids 16 to 122 (107 residues), 102.9 bits, see alignment E=5.8e-33 PF02786: CPSase_L_D2" amino acids 128 to 335 (208 residues), 192 bits, see alignment E=4e-60 PF02222: ATP-grasp" amino acids 144 to 305 (162 residues), 34.3 bits, see alignment E=7.1e-12 PF07478: Dala_Dala_lig_C" amino acids 155 to 304 (150 residues), 34.3 bits, see alignment E=7e-12 PF02785: Biotin_carb_C" amino acids 349 to 455 (107 residues), 110.2 bits, see alignment E=2.2e-35 PF00682: HMGL-like" amino acids 680 to 817 (138 residues), 39.4 bits, see alignment E=2.2e-13 PF02436: PYC_OADA" amino acids 844 to 1075 (232 residues), 131.4 bits, see alignment E=1.5e-41 PF00364: Biotin_lipoyl" amino acids 1129 to 1181 (53 residues), 23.8 bits, see alignment (E = 1.3e-08)

Best Hits

KEGG orthology group: K01958, pyruvate carboxylase [EC: 6.4.1.1] (inferred from 100% identity to dvu:DVU1834)

Predicted SEED Role

"Pyruvate carboxylase (EC 6.4.1.1)" (EC 6.4.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.4.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72B06 at UniProt or InterPro

Protein Sequence (1234 amino acids)

>DVU1834 pyruvate carboxylase, putative (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MAIKTFEQVMEEVRGKAILVANRGIPARRICRSIRERFDAVAVMTATDVDKTSPAASAAQ
ELLLLGADPRAYLDIDRIISLAKQRGVVAIHPGWGFASEDDRFPSKCHEAGLTFIGSTAE
AMNLLGNKVQVRKLARKLGVPVVPGSEGAVDIPTARKLIDEIGLPIMLKAEGGGGGRGIF
AIRDESELDDAFFKASTMAQASFGNPRLFVEKYLESVRHIEIQVIADMYGNAFAFDERDC
SIQRNHQKLIEITPSPWPGITPELREKLKEYSKMLVREVGYHSLATVEFLVTASGEAYLI
EVNTRLQVEHGITECRYGIDLVEEQIAVAFGAQLRLTEENTKPVHHAMQVRINCEDPQAG
FSPNSGLVSRYVSPGGPGVRLDSNMCAGYEFPPNYDSAGSLLITYGQGWQKVLGIMERCL
SEYIIGGLKTTIPFYKQVMKHPRFRAGDFDTNFIAETPELMCYTDLAPEGERLARLVAEI
SAKGFNPYVQLGEYRTRETPRMPKFEPVLPHIPGQVRRNPSPYPHGDRGALLDYLRDAGH
VHFTDTTARDITQSNSGNRFRLAEDALMGPYLDNCNFFSLENGGGAHFHVAMMANMTYPF
SEAAEWNKFAPKTLKQILIRSTNVLGYKPQPRNLMRITGEMICEHYQVIRCFDFLNHVEN
MRPFAEVALNRNDVVFEPALSLSWARGFDVAHYVGVTEAILRMVGDVAGFGPEQASRSII
LGLKDMAGVCPPRFMTELVSTLRKRWPSLVLHCHRHYTDGLFVPAVGAAAKAGAHIVDTA
IGASVRWYGQGDVLSMAAYLEDELGLRTNLNKTMIRDCNFVLKQVMPFYDRYCAPYFQGI
DYDVVEHGMPGGATSSSQAGAMKQGYIHLLPYMLKFLAGTRKIVRYHDVTPGSQITWNTA
FLAVTGAHKRGGEDEVRYLLEVLDNVTRHPESDLSEDMKKARLAIYQDCNDAFRDLLLGK
FGRLPLGFPDEWVYRSAFGNEWRKAMASRTEASPLDSLAPVDLALEERGFIDIVRRKPTE
EEFVMYLNHPGDAIKTIQFKARFGNANNLPLDVWFEGLQPGEELNFTDSSGKPHHLVILS
ISRPNDAGYSVIRYVLDSEIMSCEAQVKQSSVADIKGVEMADRANPMHVAAPSNGDLWVM
YVHPGDVVKKGEELFNVSIMKQEKAVLAPMDAMVKRVLKTADYRESKQMVAVREGELVVE
LCPIPKMCPNHACGHPITLDGIDFCPYCGERLDA