Protein Info for DVU1790 in Desulfovibrio vulgaris Hildenborough JW710

Annotation: MutS2 family protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 771 PF00488: MutS_V" amino acids 336 to 515 (180 residues), 89.1 bits, see alignment E=3.7e-29 PF01713: Smr" amino acids 696 to 771 (76 residues), 83.2 bits, see alignment E=1.1e-27

Best Hits

KEGG orthology group: K07456, DNA mismatch repair protein MutS2 (inferred from 100% identity to dvu:DVU1790)

Predicted SEED Role

"Recombination inhibitory protein MutS2" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72B48 at UniProt or InterPro

Protein Sequence (771 amino acids)

>DVU1790 MutS2 family protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MTLEARTLRALEYDKVLHHLARYCVSEAGREACLALAPCPGSDALADATALLEDARRWSE
HTGFRLSVFPPLGGVFRYLEGQSAVLDLEALWALRQMLTQARALVTSVAEGAATAGRWET
LSTLTLRTPLPLRSVSGLERCVSEDGLLRDESSPELLLARQEIRRLHQQCTRKVKDYAQQ
YNILHYLQDEFMTLSSDRYVLPLKSNFKGRLQGIIHDYSQTGETCYFEPMFLVEVNNRLQ
ELKREERAEERKVLTYLTDLVRGELAGVRAAFDLLVTADVLLAKCALAAAFDGSVVRMES
GRTLDLRKARHPLLVLAGHAVQPVDIALGDGQRCLVISGGNAGGKTVSLKTAGLITLMAL
SALPVPAAPGSSLPAWTTVHAFIGDEQSLEDHVSTFTAQITHLGRVWDGLDDSTLVILDE
FGAGTDPAQGAALAQAVLDELMAHGASVIAATHFPALKAYALSREGVRAASVLFDPKSRK
PLYTLAYDQVGASQALDVAREHGLPESVLRRAENYLLLDGEDTSALVARLNSLAVDRERE
LDALRAEEEKYRAKRMKLEERFARERETLFRDIQAQAQSVLRDWKDGKVSHKQTLKALSK
VRETLSTQPAESQAEQEQPVSVDVATLRQGQPVFHRPWGKKAVVAEVDLRKSRVRIDMSG
VFLWAEARDLAPSDARPETRASVTQTVSASPVPMRLDLRGMRADVALSELEKGVDNALLA
GRSVLEIIHGRGTGALRKEVHAYLRQSPAIATFSLAPEDQGGDGVTLVEFR