Protein Info for DVU1468 in Desulfovibrio vulgaris Hildenborough JW710

Name: htrA
Annotation: peptidase/PDZ domain protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 482 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details TIGR02037: peptidase Do" amino acids 30 to 475 (446 residues), 486.8 bits, see alignment E=3.1e-150 PF00089: Trypsin" amino acids 92 to 256 (165 residues), 76.3 bits, see alignment E=8.1e-25 PF13365: Trypsin_2" amino acids 94 to 232 (139 residues), 124.7 bits, see alignment E=1.3e-39 PF00595: PDZ" amino acids 262 to 346 (85 residues), 40.8 bits, see alignment E=5.9e-14 amino acids 384 to 466 (83 residues), 28 bits, see alignment E=5.7e-10 PF13180: PDZ_2" amino acids 269 to 359 (91 residues), 57.9 bits, see alignment E=2.6e-19 amino acids 388 to 470 (83 residues), 41.2 bits, see alignment E=4.1e-14 PF17820: PDZ_6" amino acids 295 to 348 (54 residues), 34.7 bits, see alignment 3e-12 amino acids 413 to 457 (45 residues), 29.5 bits, see alignment 1.3e-10

Best Hits

KEGG orthology group: K01362, [EC: 3.4.21.-] (inferred from 100% identity to dvl:Dvul_1611)

Predicted SEED Role

"HtrA protease/chaperone protein"

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.-

Use Curated BLAST to search for 3.4.21.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72C16 at UniProt or InterPro

Protein Sequence (482 amino acids)

>DVU1468 peptidase/PDZ domain protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MVRTPRYFALLLLMVAVVLSSTAQAASLPDFRELAKNAGAAVVNISTEKTVQAPENPFGD
MLRNAPQGTPFDRFFEQFERFHGKMRPQKQRSLGSGFILSADGYIVTNNHVIADADVIHV
NIENETGKSASYDAKVIGTDEETDLALLKIDAKRQLPVLRFGDSDSLEVGEWLMAIGNPF
GLDHSVTAGILSAKGRDIRSGPFDNFLQTDASINPGNSGGPLINMKGEVIGINTAIVASG
QGIGFAIPSNMAARIIDQLKSDKKVRRGWIGVTIQDVDENTARALGLGEPRGALVGSVMP
GEPADKAGIKAGDILLKVEGEDIADSGRLLRRVAALKPGETAKITLWRNGQTKTVNLTLG
ERTAEHLAAQGGTPRQTPESKQQASSSLGLTVRPPNAEEARALKLDRPQGLLVIAVEEGR
PAADADIRAGDVVLSANLHPVNSTADLAKVVQEDAKRRGAVMLQIQRRGQTFFRTIPIEA
EK