Protein Info for DVU1337 in Desulfovibrio vulgaris Hildenborough JW710

Name: lon
Annotation: ATP-dependent protease La (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 821 PF02190: LON_substr_bdg" amino acids 17 to 213 (197 residues), 174.4 bits, see alignment E=8.3e-55 TIGR00763: endopeptidase La" amino acids 19 to 784 (766 residues), 965.5 bits, see alignment E=1.4e-294 PF00004: AAA" amino acids 364 to 502 (139 residues), 86 bits, see alignment E=9.6e-28 PF07728: AAA_5" amino acids 364 to 498 (135 residues), 32.8 bits, see alignment E=2e-11 PF22667: Lon_lid" amino acids 525 to 580 (56 residues), 83.9 bits, see alignment 1.4e-27 PF05362: Lon_C" amino acids 584 to 786 (203 residues), 302.8 bits, see alignment E=3.3e-94

Best Hits

Swiss-Prot: 100% identical to LON_DESVH: Lon protease (lon) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 100% identity to dvu:DVU1337)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72CE6 at UniProt or InterPro

Protein Sequence (821 amino acids)

>DVU1337 ATP-dependent protease La (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MTDTGREGLQNREEGFELPLMSLREVVMFPRSIVPLFVGREASIKAIESAISDYGKKIFL
VAQREPELEKPGPEDLFEVGTVSKILQLLRLPDGTIKVLFEGLYRARWDGTADAIIGADD
AYPRVRVTRIEQESSEDDDEALVRATHEALDEYGKINKKLAQETLVAISALSDAARLADA
IMPHLKVDYRRKQELLEVESGAERLEKVYELLQGEIAVASLEKRIKSRVKNQMERNQREY
YLNEQIKAIHKEMGREDDPQAEVNELEARLAEKSMPEEAREKALREMKKLRQMPPSSAEY
TVVRNYVDWILDLPWNTLKETEIDIDNARSILDADHYGLEKPKERILEYLAVQKLVNRLK
GPILCLVGPPGVGKTSLAKSVAKATGREFVRLSLGGVRDEAEIRGHRRTYVGALPGKIIQ
SLKRVKHNNPLFCLDEIDKMSTDFRGDPSSALLEVLDPEQNSTFNDHYLDMDYDLSQVFF
ITTANSLHSIPLPLQDRMEIIRLPGYLETEKRRIAHDFLLPKQVEAHGLAASNLRISDNA
VLEIIRSYTREAGVRNLEREIASVCRKAAMQVVEAGDKEKTLTVSRQNLGNFLGVKKYRH
GEREDTSQVGVCTGLAWTEMGGELLVVETALMPGSGRVEITGKLGDVMTESAKAALSYLR
SRSDLFGLRPDFHKEIDIHVHVPEGATPKDGPSAGITLATSMVSALLGIPVRNDVAMTGE
ITLRGRVLPIGGLREKLLAAHRGQIGKVLVPRENEKDLKEVPGEILKGLEIVFVDHVDEV
LPQALMAQAESIFGGRTQSTPLYAKLRKDAQDGGATMPTAQ