Protein Info for DVU1191 in Desulfovibrio vulgaris Hildenborough JW710

Name: lon
Annotation: ATP-dependent protease La, putative (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 856 PF02190: LON_substr_bdg" amino acids 90 to 282 (193 residues), 163.3 bits, see alignment E=1.8e-51 TIGR00763: endopeptidase La" amino acids 92 to 853 (762 residues), 958.9 bits, see alignment E=1.3e-292 PF00004: AAA" amino acids 434 to 571 (138 residues), 89.8 bits, see alignment E=5.4e-29 PF07728: AAA_5" amino acids 434 to 568 (135 residues), 33.5 bits, see alignment E=9.7e-12 PF22667: Lon_lid" amino acids 596 to 647 (52 residues), 73 bits, see alignment 3e-24 PF05362: Lon_C" amino acids 652 to 853 (202 residues), 277.8 bits, see alignment E=1.3e-86

Best Hits

Swiss-Prot: 71% identical to LON_DESDA: Lon protease (lon) from Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 100% identity to dvu:DVU1191)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72CU2 at UniProt or InterPro

Protein Sequence (856 amino acids)

>DVU1191 ATP-dependent protease La, putative (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MTHTNDDTKSTTIATVDTDDKPDTVVDDGDTLAAVQPADTPEADGKSASGADDENAPAAE
ADDDAGTPESDDASPASDDAAQETPEIPQELPVLPVRDVVVFNYMILPLFVGREKSVQAV
DAALNGSRYLMVCTQHDEQVDDPTPDDLHHTGTVVMIMRMLKMPDGRIKVLVQGVTRAHV
DAFTSEEPHISARVTPMPEVDSGPLTVEQEAMMRTAREQSEKILSLRGISTSEIMSVLNS
VDEPGRLADLIAANLRMKVSDAQDILECVDPVARLELVNKQLMKEAEVASMQAKIQSMAR
EGMDKAQKDYFLREQLKAIRRELGESGNEDEELEELARALDIAKLPRDVRKEADKQLRRL
AAMHPDSSEATVTRTYLEWLSELPWRKLSRDRLDIRKAKVILDEDHFGLDKVKDRILEYL
SVRKLNPDSKGPILCFAGPPGVGKTSLGRSIARTLGRKFQRISLGGMRDEAEIRGHRRTY
IGSMPGRIIQSLKQCGTRNPVIMLDEIDKIGADFRGDPSSALLEVLDPEQNWSFSDHYLN
VPFDLSKVMFICTANQLDTIPAPLRDRMEIISIPGYTMQEKVAIARRHLVPRQATSNGLG
ENEITIGDAAIETLVRGYTREAGLRNLEREIGSVCRKLARRKAEGSKGPFRVTPALTQKL
LGAPRFLEDEHEKELLPGVALGLAWTPYGGEVLNVEVSPLKGKGKLILTGQLGDVMKESA
QAAVSYARSRAEELDIDPGFAEDRDLHIHVPAGATPKDGPSAGVTLVTALISALTGRPVR
SDLCMTGEITLRGRVLPVGGIKEKILAGVARGLKHVVIPAQNAKDLEDVPADLLRRIEVH
LASHIDDVLPVAFKPN