Protein Info for DVU0894 in Desulfovibrio vulgaris Hildenborough JW710
Name: aroC
Annotation: chorismate synthase (TIGR)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to AROC_DESVH: Chorismate synthase (aroC) from Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
KEGG orthology group: K01736, chorismate synthase [EC: 4.2.3.5] (inferred from 100% identity to dvl:Dvul_2090)MetaCyc: 55% identical to chorismate synthase (Escherichia coli K-12 substr. MG1655)
Chorismate synthase. [EC: 4.2.3.5]
Predicted SEED Role
"Chorismate synthase (EC 4.2.3.5)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 4.2.3.5)
MetaCyc Pathways
- superpathway of aromatic amino acid biosynthesis (17/18 steps found)
- superpathway of L-tryptophan biosynthesis (12/13 steps found)
- superpathway of L-phenylalanine biosynthesis (9/10 steps found)
- superpathway of L-tyrosine biosynthesis (9/10 steps found)
- chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
- chorismate biosynthesis II (archaea) (10/12 steps found)
- chorismate biosynthesis I (6/7 steps found)
- superpathway of chorismate metabolism (31/59 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.2.3.5
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q72DN5 at UniProt or InterPro
Protein Sequence (354 amino acids)
>DVU0894 chorismate synthase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710) MSGNTLGRLFRLTTYGESHGAGLGGVIDGCPAGIALDEAVIQRELDLRRPGGNSASTTRQ EPDRVRLLSGVFEGVTTGTPIAFHVENVDQRSRDYGEIARLYRPGHADFTYDAKFGVRDY RGGGRASGRETLSRVAGGAIAQALLARHGIAVRAFTVELGGVPADLVDVAGAQQRPFFSP DPDVVEAWEDMVRTVKGEGDTLGGIVQVEATGVPAGLGEPVFDKLDAVLAYALMSVGAVK GVEVGAGFEAARMHGSDNNDPIVPSGFFTNHAGGILGGISNGETIVLRAAVKPIPSIAQE QITIDRDGKPSALFIAGRHDISAIPRIVPVLKAMTALVLADMLLMQRRMATPQP