Protein Info for DVU0889 in Desulfovibrio vulgaris Hildenborough JW710
Annotation: phosphonopyruvate decarboxylase-related protein (TIGR)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01618, [EC: 4.1.1.-] (inferred from 100% identity to dvu:DVU0889)Predicted SEED Role
"2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal type (EC 5.4.2.1)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 5.4.2.1)
MetaCyc Pathways
- homolactic fermentation (11/12 steps found)
- hexitol fermentation to lactate, formate, ethanol and acetate (16/19 steps found)
- Bifidobacterium shunt (13/15 steps found)
- glycolysis II (from fructose 6-phosphate) (10/11 steps found)
- glycolysis III (from glucose) (10/11 steps found)
- glycolysis I (from glucose 6-phosphate) (11/13 steps found)
- superpathway of anaerobic sucrose degradation (15/19 steps found)
- Rubisco shunt (8/10 steps found)
- glycolysis IV (8/10 steps found)
- gluconeogenesis I (10/13 steps found)
- glycolysis VI (from fructose) (8/11 steps found)
- glycolysis V (Pyrococcus) (7/10 steps found)
- superpathway of glucose and xylose degradation (12/17 steps found)
- superpathway of glycolysis and the Entner-Doudoroff pathway (12/17 steps found)
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (18/26 steps found)
- superpathway of N-acetylneuraminate degradation (15/22 steps found)
- ethene biosynthesis V (engineered) (17/25 steps found)
- photorespiration II (6/10 steps found)
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (14/22 steps found)
- superpathway of hexitol degradation (bacteria) (11/18 steps found)
- Entner-Doudoroff pathway III (semi-phosphorylative) (4/9 steps found)
- glycerol degradation to butanol (9/16 steps found)
- gluconeogenesis II (Methanobacterium thermoautotrophicum) (9/18 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (15/27 steps found)
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (14/26 steps found)
- Methanobacterium thermoautotrophicum biosynthetic metabolism (22/56 steps found)
KEGG Metabolic Maps
- 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Ascorbate and aldarate metabolism
- Benzoate degradation via hydroxylation
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Biphenyl degradation
- Fluorene degradation
- Glycolysis / Gluconeogenesis
- Phenylalanine metabolism
- Phenylpropanoid biosynthesis
- Purine metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Tyrosine metabolism
- Ubiquinone and menaquinone biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.-, 5.4.2.1
Use Curated BLAST to search for 4.1.1.- or 5.4.2.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q72DP0 at UniProt or InterPro
Protein Sequence (379 amino acids)
>DVU0889 phosphonopyruvate decarboxylase-related protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710) MMAKLVVCIIDGMADPPPPAGGVTPLAAAHTPHCDTLARHSVAGLCHVIQPEAVPGSEAG LSALLCCEAAASIARGPVEALAQGDPVAPHETVWRLNLVSLGPRGNYYNPAPLLDAATET AARKMLDRALGTQGYSLLGGKGFRHLCAGTEPPVLRDGPQDVCGMTPDTGQADLNSYCPR LARAMTEANVLFRRSRMDLAVWPWGAGTMPDLPGFAETTGQTGALAGGVPLARGLALALG MTAPSIAGATGGIDTDLGAKTRAAIALAAGHDVVYLHVEAPDLHAHALDRVAKRRAIERI DAEVVGPLHMALPDATLLITCDHATDCATGRHMAIPVPFILHKPDGPQDGIATFSEAASA RTGIRIDSAATLVRLALAD