Protein Info for DVU0811 in Desulfovibrio vulgaris Hildenborough JW710

Name: dnaK
Annotation: dnaK protein (TIGR)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 636 TIGR02350: chaperone protein DnaK" amino acids 3 to 599 (597 residues), 976.2 bits, see alignment E=2.7e-298 PF00012: HSP70" amino acids 4 to 598 (595 residues), 876.8 bits, see alignment E=6.4e-268 PF06723: MreB_Mbl" amino acids 135 to 371 (237 residues), 51.1 bits, see alignment E=9.1e-18

Best Hits

Swiss-Prot: 100% identical to DNAK_DESVV: Chaperone protein DnaK (dnaK) from Desulfovibrio vulgaris subsp. vulgaris (strain DP4)

KEGG orthology group: K04043, molecular chaperone DnaK (inferred from 100% identity to dvl:Dvul_2166)

MetaCyc: 63% identical to chaperone protein DnaK (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein DnaK" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q72DW8 at UniProt or InterPro

Protein Sequence (636 amino acids)

>DVU0811 dnaK protein (TIGR) (Desulfovibrio vulgaris Hildenborough JW710)
MGKIIGIDLGTTNSCVYVMEGKDPKCITNPEGGRTTPSVVAFTDKERLVGDIAKRQAVTN
PERTVFAVKRLMGRRGDAPEVGRWKEHSPYRIVAGANGDAAVEVQGRPYSAPEISAMILG
KLKADAEAYLGETVTEAVITVPAYFNDAQRQATKDAGRIAGLDVKRIINEPTAASLAYGF
DRKANEKIAVFDLGGGTFDISILEVGDNVVEVRATNGDTFLGGEDFDQRIISYLVDEFRR
ENGGIDLARDRMALQRLKEAAEKAKKDLSTSMETEVNLPFITADQTGPKHLMMKLSRAKL
EKLVEDLVERTVEPCRKALADAGLTAAQIDEVVLVGGMTRMPLVQKRVSEFFGKEPNRSV
NPDEVVAMGAAIQGGILAGDVKDVLLLDVTPLSLGIETLGGVFTRLIERNTTIPTRKSQT
FTTAADNQPSVSIHVLQGERPMASDNMTLGRFELTGIPPAMRGVPQIEVSFDIDANGIVN
VAAKDLGTGKEQSIRITASSGLSEDEIQRLVKEAEAHADDDKKKQELIEARNQADGLIYG
TEKSIRDLGDKLDAALKADIETKVTALRGLLESEDVDAIKKASDELAQASHKLAEQLYKQ
QAQAGGPEAGAQPEGDAGARKQDDDVVDADYTEVKK