Protein Info for DVU0664 in Desulfovibrio vulgaris Hildenborough JW710
Annotation: cysteine desulfurase (TIGR)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 63% identical to NIFS2_ANAVT: Cysteine desulfurase 2 (nifS2) from Anabaena variabilis (strain ATCC 29413 / PCC 7937)
KEGG orthology group: K04487, cysteine desulfurase [EC: 2.8.1.7] (inferred from 100% identity to dvu:DVU0664)MetaCyc: 47% identical to mitochondrial cysteine desulfurase NFS1 (Homo sapiens)
Cysteine desulfurase. [EC: 2.8.1.7]; 2.8.1.7 [EC: 2.8.1.7]; 2.8.1.7 [EC: 2.8.1.7]; 2.8.1.7 [EC: 2.8.1.7]
Predicted SEED Role
"Cysteine desulfurase (EC 2.8.1.7), NifS subfamily" in subsystem Alanine biosynthesis or Nitrogen fixation (EC 2.8.1.7)
MetaCyc Pathways
- L-alanine biosynthesis III (1/1 steps found)
- L-cysteine degradation IV (1/1 steps found)
- superpathway of L-alanine biosynthesis (3/4 steps found)
- superpathway of thiamine diphosphate biosynthesis II (8/11 steps found)
- superpathway of thiamine diphosphate biosynthesis I (7/10 steps found)
- cytidylyl molybdenum cofactor sulfurylation (1/2 steps found)
- thiazole component of thiamine diphosphate biosynthesis II (4/7 steps found)
- bis(guanylyl molybdopterin) cofactor sulfurylation (1/3 steps found)
- thiazole component of thiamine diphosphate biosynthesis I (3/6 steps found)
- tRNA-uridine 2-thiolation (thermophilic bacteria) (2/5 steps found)
- tRNA-uridine 2-thiolation (mammalian mitochondria) (1/4 steps found)
- tRNA-uridine 2-thiolation (yeast mitochondria) (1/4 steps found)
- molybdopterin biosynthesis (1/6 steps found)
- tRNA-uridine 2-thiolation (cytoplasmic) (1/8 steps found)
- [2Fe-2S] iron-sulfur cluster biosynthesis (2/10 steps found)
- tRNA-uridine 2-thiolation and selenation (bacteria) (2/11 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.8.1.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q72EB4 at UniProt or InterPro
Protein Sequence (394 amino acids)
>DVU0664 cysteine desulfurase (TIGR) (Desulfovibrio vulgaris Hildenborough JW710) MKTIYFDNNATTQVDPAVLEAMLPFLTEMYGNPSSMHTFGGKVGRYVTEARAQVAAAIGA APEEIIFTSCGSESDNTAIRSALQAQPDRRHIITTRVEHPAVLSLAQHLEKNGVEVSLLG VDAKGRMDLDELRAAIRKDTAIISIMTANNETGTIFPIAEAGAIAHEHGVPFHTDAVQAV GKVALDMKTMPVDYLALSGHKLHAPKGVGALYVRRGTAYRPFLRGGHQERGRRAGTENVA SIVALGKACELATAAMHEENTQVRALRDRLESGLLAAIPDAVVNGDTANRLPNTSNIAFK YVEGEAILLMLDQHGVCASSGSACTSGSLEPSHVLRAMGVPFTFAHGSIRFSLSRFNTME DVEYVVRELPPIIRRLREISPFRGEMTGKPACTC