Protein Info for SO4477 in Shewanella oneidensis MR-1

Name: cpxR
Annotation: transcriptional regulatory protein CpxR (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 228 PF00072: Response_reg" amino acids 4 to 113 (110 residues), 104 bits, see alignment E=5.3e-34 PF00486: Trans_reg_C" amino acids 152 to 225 (74 residues), 63.8 bits, see alignment E=1.3e-21

Best Hits

Swiss-Prot: 60% identical to CPXR_SHIFL: Transcriptional regulatory protein CpxR (cpxR) from Shigella flexneri

KEGG orthology group: K07662, two-component system, OmpR family, response regulator CpxR (inferred from 100% identity to shn:Shewana3_0253)

MetaCyc: 60% identical to DNA-binding transcriptional dual regulator CpxR (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Copper-sensing two-component system response regulator CpxR" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8E918 at UniProt or InterPro

Protein Sequence (228 amino acids)

>SO4477 transcriptional regulatory protein CpxR (NCBI ptt file) (Shewanella oneidensis MR-1)
MSRILLIDDDLGLSELLGQLLELEGFKLTLAYDGKQGLELALATDYDLILLDVMLPKLNG
FEVLRALRQHKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELIARIRAIIRRSH
LTAQEIHATPAQEFGDLRLDPSRQEAYCNEQLIILTGTEFTLLHTLALHAGELMNKEELN
EIVLGKKLMPFDRSLDMHLSNLRKKLPERSDGRPRVKTIRGKGYIWLP