Protein Info for SO4312 in Shewanella oneidensis MR-1

Annotation: adenylate cyclase CyaA, putative (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 804 PF12633: Adenyl_cycl_N" amino acids 10 to 202 (193 residues), 208.8 bits, see alignment E=8.5e-66 PF01295: Adenylate_cycl" amino acids 210 to 794 (585 residues), 762.8 bits, see alignment E=2.8e-233

Best Hits

KEGG orthology group: K05851, adenylate cyclase, class 1 [EC: 4.6.1.1] (inferred from 100% identity to son:SO_4312)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8E9H1 at UniProt or InterPro

Protein Sequence (804 amino acids)

>SO4312 adenylate cyclase CyaA, putative (NCBI ptt file) (Shewanella oneidensis MR-1)
MDQQGHFPDIAERLNQVRIARALALLSPLQKHLFRLIPFLIQQNSVQYPGFVDPNTPCGI
YGYKAGSLEAQACDVFKLPFIATEVDFYAFEGVYAMGSTASFGQNAKSDVDVWLVHHADL
CDDDLALIKLKTERLTAWFAEYQFEVNFYLVHPLQFCGDMSQRTVCQSSMAHEHSGSTQH
WLLLEEFYRSQIRLAGKIIAWWPDAKLNPELLSLGNVHELPASEYFGASLWQLYKGLNKP
HKALIKVLLLEAYASEYPHSQLLCDRLWQKTLAGDFSTANDAYYAIYEVIEAYLLKQNDS
RRLEIVRRCFYLKCGVFLSLSNQGKDWRYAKMQKLVQEWQWPNSLITTLDDCEHWHSGQL
NWFNEQLNELLLASYQTLLRFASTHELNEGLKIEELGMLTRKLHTYFSQDEDQIAKLNLL
WSRSVAEAEVTMVSSTKENQYYLYRQGPKPLNLLGDSAICKGKSPSALMIWACLNGVSTP
ETKWYEFGQSKVKSQRLTDASKRLLNFIDHDWRVSKLDLCQPWHFRKLIFILNLDCDPTI
GWRGQEMMVDVMNANVFSLGRKQENMLGALDAICLNSWGEWQCHRFEGETAVLQALAFVT
PGLRRATHPVDMDVISCSQRLRPQLKLAVKNLLKQTVRLCQQVQQSSTLVQPLQISHTRY
GIFFNPLGMAYQDLSDAKSFYQQLARSHLVQLPRPELGDDPFSSMPNIIQNFAAKGAIQY
FLRQRTDSLDVFILDEENQLSHYVQSGSDMSELVNKVSHHYVFDEFYASKARFNIPQFFH
LVRVAGELTVRPFGVDMNNANVEF