Protein Info for SO3509 in Shewanella oneidensis MR-1

Name: hex
Annotation: beta-hexosaminidase b precursor (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 896 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF03173: CHB_HEX" amino acids 53 to 215 (163 residues), 187.8 bits, see alignment E=2.3e-59 PF02838: Glyco_hydro_20b" amino acids 235 to 357 (123 residues), 40.4 bits, see alignment E=9.8e-14 PF00728: Glyco_hydro_20" amino acids 361 to 775 (415 residues), 353.6 bits, see alignment E=2.8e-109 PF03174: CHB_HEX_C" amino acids 819 to 892 (74 residues), 96 bits, see alignment E=2e-31

Best Hits

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 100% identity to son:SO_3509)

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8CVD2 at UniProt or InterPro

Protein Sequence (896 amino acids)

>SO3509 beta-hexosaminidase b precursor (NCBI ptt file) (Shewanella oneidensis MR-1)
MSKTIAATAILFALGLSACSQGPKTVNTPAPSSAEQPTPALLTQAQLQQFGDNLGVTYRV
LTNRPDDNCDKAAAEGRCFVAEIDFVPEVDLIGKEWAIYFSQMRPVQSVEGKEFSITHIK
GDLYRIAPTEAFSGFSKGVKKTLRFRGELWQLSETDAMPNYYIVAGDLSPVVIASTQVKQ
DPETRMEVRPYVEPFTDMVKQYSRTDADKLAPATASQLFSNNQNVSEDASLAVNTIIPTP
KTVVLHSNDKVVSLSSGIKLDVASVSSPSAEKQSFKTDQVAAALERLARLGVKESEQGLV
MKLSWRQGAEGSYLLDIKPDGIKIAAGDAAGFSYALSSLTSLIDVQDLRVNAMTIEDSPR
YPFRGMHIDVARNFHSKAMIFALIDQMAAYKLNKLHLHMADDEGWRLEIDGLPELTDIGS
KRCHDLEENTCLLPQLGSGPFAESSVNGFYSKQDYIDILKYANARQIQVIPSMDMPGHSR
AAIKSMEARYRKLLAQGKPTEAKTYLLSDAADTTVYSSVQYYNDNTLNVCMESTYQFVDK
VIDEIAKLHQAAGQPLTRYHIGADETAGAWKQSPECLSFVANNDKGVKSIEDLGAYFIER
ISNQLAEKGIEAAGWSDGMSHVRPSYMPAKVQSNIWDVIAYKGYEHANQQVNNGWDVVLS
NPEVLYFDFPYEADPKEHGYYWASRATNAHKVFSFMPDNLVANAEQWTDLQNLPFEADDR
ARTDEKGKKSGPREQGKNFAGLQGQLWSETIRSNDTVEYMIFPRLLMLAERAWHQAEWEV
PYQYQGALYNQSTGHFTAAMRDAQAQSWQQMANTLGHKEFIKLDKAGIDYRVPTVGAKIQ
GGKLFANVAYPGLKMEFRQANGQWQAYQAGQAVTAPVEIRAIAADGIRKGRSLIVN