Protein Info for SO2486 in Shewanella oneidensis MR-1

Name: eda
Annotation: 2-deydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01182: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase
  • amino acids 12 to 210 (199 residues), 272.9 bits, E=6.4e-86
• PF01081: Aldolase
  • amino acids 12 to 205 (194 residues), 270.3 bits, E=4e-85

Best Hits

Swiss-Prot: 62% identical to ALKH_ECO57: KHG/KDPG aldolase (eda) from Escherichia coli O157:H7

KEGG orthology group: K01625, 2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate aldolase [EC: 4.1.2.14 4.1.3.16] (inferred from 100% identity to son:SO_2486)

MetaCyc: 62% identical to 2-dehydro-3-deoxy-phosphogluconate aldolase (Pseudoalteromonas atlantica T6c)
2-dehydro-3-deoxy-phosphogluconate aldolase. [EC: 4.1.2.14, 4.1.2.55]

Predicted SEED Role

"4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) @ 2-dehydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14)" (EC 4.1.2.14, EC 4.1.3.16)

MetaCyc Pathways

• superpathway of glycolysis and the Entner-Doudoroff pathway (15/17 steps found)
• Entner-Doudoroff pathway I (8/9 steps found)
• Entner-Doudoroff shunt (2/2 steps found)
• trans-4-hydroxy-L-proline degradation I (3/5 steps found)
• D-glucosaminate degradation (1/3 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (5/9 steps found)
• D-fructuronate degradation (1/4 steps found)
• 4-deoxy-L-threo-hex-4-enopyranuronate degradation (1/5 steps found)
• D-galacturonate degradation I (1/5 steps found)
• 3,6-anhydro-α-L-galactopyranose degradation (2/7 steps found)
• superpathway of β-D-glucuronosides degradation (2/7 steps found)
• superpathway of hexuronide and hexuronate degradation (2/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (6/31 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glyoxylate and dicarboxylate metabolism
• Pentose and glucuronate interconversions
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.14 or 4.1.2.55 or 4.1.3.16

Sequence Analysis Tools

See Q8EEA1 at UniProt or InterPro

Protein Sequence (213 amino acids)

>SO2486 2-deydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (NCBI ptt file) (Shewanella oneidensis MR-1)
MLENNWSLQPQDIFKRSPIVPVMVINKIEHAVPLAKALVAGGISVLEVTLRTPCALEAIT
KIAKEVPEALVGAGTILNEAQLGQAIAAGAQFIITPGATVELLKAGMQGPVPLIPGVASI
SEVMTGMALGYTHFKFFPAEASGGVDALKAFSGPLADIRFCPTGGITPSSYKDYLALKNV
DCIGGSWIAPTDAMEQGDWDRITQLCKEAIGGL