Protein Info for SO2465 in Shewanella oneidensis MR-1

Annotation: surface protein, putative (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02368: Big_2
  • amino acids 17 to 94 (78 residues), 29.4 bits, E=3.1e-11
  • amino acids 115 to 201 (87 residues), 26 bits, E=3.7e-10
  • amino acids 211 to 288 (78 residues), 28.7 bits, E=5.2e-11
  • amino acids 309 to 383 (75 residues), 23.7 bits, E=1.9e-09
  • amino acids 406 to 492 (87 residues), 30.7 bits, E=1.3e-11
  • amino acids 599 to 674 (76 residues), 22.9 bits, E=3.5e-09

Best Hits

KEGG orthology group: None (inferred from 100% identity to son:SO_2465)

Predicted SEED Role

"Dihydrolipoamide dehydrogenase (EC 1.8.1.4)" in subsystem Glycine cleavage system or Leucine Degradation and HMG-CoA Metabolism or Photorespiration (oxidative C2 cycle) or TCA Cycle (EC 1.8.1.4)

MetaCyc Pathways

• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (18/22 steps found)
• 2-oxoglutarate decarboxylation to succinyl-CoA (3/3 steps found)
• 2-oxoisovalerate decarboxylation to isobutanoyl-CoA (3/3 steps found)
• glycine biosynthesis II (3/3 steps found)
• glycine cleavage (3/3 steps found)
• pyruvate decarboxylation to acetyl CoA I (3/3 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Citrate cycle (TCA cycle)
• Glycine, serine and threonine metabolism
• Glycolysis / Gluconeogenesis
• Pyruvate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.4

Use Curated BLAST to search for 1.8.1.4

Protein Sequence (905 amino acids)

>SO2465 surface protein, putative (NCBI ptt file) (Shewanella oneidensis MR-1)
MWMVHYSAQLDVTQAVVTALQVTPTTEPVPVGLTKPFTAIATLSDGRTLDVTNDPALSWS
SSSLSIATISSNQPSSNGIATGVTTGTATITATAYVDGTLFNATAQLDVTKAVLTALQVT
PVTESVPTGLTKQFTAIAILSDGRTLDVTNDPAISWNSTPSTVATISSNQAEDNGIITGV
APGTAMITASVTANRTFFSATAQLTVTNAVVTALQVTPVTESVPVGLTKAFTAIATLSDG
RTQDLTNDPALSWSSSSLSIATISSNQPSNNGIATGVTTGTATITATAYVDGTLFNATAQ
LDVTKAVLTALQVTPATESVPAGLTKKFTAIATLSDGSTQDVTNDPSLSWSSNALNIVTI
SSNQSDSNGIATGVSIGTATITASGTVNRVFISATAQLTVSEAVITALEVSPVTEFVPVG
LTKAFTAIATFSDGRMRDVTNEPTLSWSSNAPSIATISSSQPDNNGLATGVSTGIATITA
SGTVNRTFFSATAQLTVTDAVITALEISPTPQIVPVGLTKTFIATAIFSDGRMQDITNDP
AISWSSTPSSVAIISSNQPGNNGVATGITPGIATITVSGSANRTFFSATAQLTVTNAVVT
ALAIEPKTELVPIGLTKPFSAIATMSDGEMIDVTNEPTLSWSTAPSSVATISSNQPGSNG
IATGVALGNATVTASGTTNGISFSATAQLTVTNAALVAISITPNSLDSLSLGRNTAETSR
YIQATKQLKATGQYSDGSNTDITNTVLWSTNNSGAMSVNATGVIKAGPSGIATISASLDG
ISSSVETKAVPWINVFTEPEKIRRSYAQANSFCTDLGLRLGSVNEMKALFVDATQSPTAA
PDSGYVPNNAMCATHGWPIASSCGGSSNGYWTKLSGSTYYSVHLNSGERVTSSSTSNYYA
ACMLN