Protein Info for SO2280 in Shewanella oneidensis MR-1

Annotation: bicyclomycin resistance protein (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 407 transmembrane" amino acids 18 to 40 (23 residues), see Phobius details amino acids 56 to 76 (21 residues), see Phobius details amino acids 87 to 105 (19 residues), see Phobius details amino acids 111 to 133 (23 residues), see Phobius details amino acids 145 to 166 (22 residues), see Phobius details amino acids 173 to 195 (23 residues), see Phobius details amino acids 227 to 247 (21 residues), see Phobius details amino acids 258 to 277 (20 residues), see Phobius details amino acids 289 to 310 (22 residues), see Phobius details amino acids 316 to 340 (25 residues), see Phobius details amino acids 351 to 372 (22 residues), see Phobius details amino acids 378 to 396 (19 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 21 to 390 (370 residues), 231.6 bits, see alignment E=1e-72 PF07690: MFS_1" amino acids 26 to 367 (342 residues), 142.6 bits, see alignment E=2.4e-45 PF00083: Sugar_tr" amino acids 60 to 192 (133 residues), 39.5 bits, see alignment E=5.1e-14 PF06609: TRI12" amino acids 63 to 200 (138 residues), 28.6 bits, see alignment E=7.8e-11

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 100% identity to son:SO_2280)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EET6 at UniProt or InterPro

Protein Sequence (407 amino acids)

>SO2280 bicyclomycin resistance protein (NCBI ptt file) (Shewanella oneidensis MR-1)
MDPQPSSYSSKQSNIPHLALLIPMLAAIVAITPLAIDMYLPAMATLAHSFNTDIILVQQS
LSVYLGGYALGMLCFGPLADRLGRRPMVIMGLTGFMLISFLLGLAEQINVFLGLRFLQAF
IGAAATVVVPGYIKEVYGENTAKGMSYVSLIMMLAPLLAPTIGSLILELGDWHLIFFIQS
AYTLLLLLLVIILLRMPSDKDKSSRSQKSFLGAYATVFSRPGVKMNIASGVLTSFAFFCY
LTASPFVYMEVFSLDKSLFALLFSTNVGALMLANIINTRIVGRYGSLRMLHVSTFLGALA
AAGLLGVNLLGLSYHFTVLMLIPLMGSLGIMSVNADAIVLMKFKQETGTATAVIGTLRFG
FGALAGPLLALFYNGTAVPFSALMLTAVLLVGFCQFNRPTHQAKPKQ