Protein Info for SO2259 in Shewanella oneidensis MR-1

Annotation: lipoprotein releasing system transmembrane protein LolC, putative (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 416 transmembrane" amino acids 21 to 48 (28 residues), see Phobius details amino acids 273 to 297 (25 residues), see Phobius details amino acids 304 to 323 (20 residues), see Phobius details amino acids 329 to 350 (22 residues), see Phobius details amino acids 357 to 370 (14 residues), see Phobius details amino acids 380 to 402 (23 residues), see Phobius details TIGR02212: lipoprotein releasing system, transmembrane protein, LolC/E family" amino acids 4 to 414 (411 residues), 455.4 bits, see alignment E=8.9e-141 PF12704: MacB_PCD" amino acids 27 to 220 (194 residues), 56 bits, see alignment E=6.9e-19 PF02687: FtsX" amino acids 276 to 409 (134 residues), 54.5 bits, see alignment E=1.2e-18

Best Hits

Swiss-Prot: 43% identical to LOLE_ECOLI: Lipoprotein-releasing system transmembrane protein LolE (lolE) from Escherichia coli (strain K12)

KEGG orthology group: K09808, lipoprotein-releasing system permease protein (inferred from 100% identity to son:SO_2259)

MetaCyc: 43% identical to lipoprotein release complex - inner membrane subunit (Escherichia coli K-12 substr. MG1655)
RXN-22427

Predicted SEED Role

"Lipoprotein releasing system transmembrane protein LolE"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EEV4 at UniProt or InterPro

Protein Sequence (416 amino acids)

>SO2259 lipoprotein releasing system transmembrane protein LolC, putative (NCBI ptt file) (Shewanella oneidensis MR-1)
MKGPLALSIGWRFYRARQSNSFISFISFASTAGIALGVAVLIIVLSAMNGFERELEQRLL
GVISQADVVGVNEPIADWRAVEQTALQIEGITAAAPFIRMQGLVQKPGGFQGLAVVGIDP
EQEAKVSTLSQFMSPETWQSLSEDDNHIVLGESLLKKLGLEVGDTLALYVQDLDPEHAGS
LRAAKSHRFVVSGVYRLGGELELTTAYIPMRYAANILNLHQGVTGVRISVTQVFEAPAKI
RELGYALNQSVYISDWTRTQGHLYQDIQLVRTIMYLVLVLVIGVACFNIVSTLVMAVRDK
ASEIAILMTMGLSRLSVMGIFMVQGALNGLVGCALGGVIGIATAINLSAIARDIEQLLGI
QLLSADVYFVDFLPSELHMADVSLVIATAFVMSLIATLYPAWKASRIGPAQALAGR