Protein Info for SO2221 in Shewanella oneidensis MR-1

Name: pabB
Annotation: para-aminobenzoate synthase, component I (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04715: Anth_synt_I_N
  • amino acids 20 to 160 (141 residues), 75.7 bits, E=4.5e-25
• TIGR00553: aminodeoxychorismate synthase, component I
  • amino acids 114 to 458 (345 residues), 401.3 bits, E=1.6e-124
• PF00425: Chorismate_bind
  • amino acids 202 to 455 (254 residues), 308 bits, E=5.8e-96

Best Hits

KEGG orthology group: K01665, para-aminobenzoate synthetase component I [EC: 2.6.1.85] (inferred from 100% identity to son:SO_2221)

Predicted SEED Role

"Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 2.6.1.85)

MetaCyc Pathways

• superpathway of chorismate metabolism (50/59 steps found)
• superpathway of tetrahydrofolate biosynthesis and salvage (10/12 steps found)
• L-citrulline biosynthesis (7/8 steps found)
• L-glutamate and L-glutamine biosynthesis (6/7 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• superpathway of tetrahydrofolate biosynthesis (8/10 steps found)
• 4-aminobenzoate biosynthesis I (2/2 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• superpathway of L-citrulline metabolism (9/12 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (1/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (1/4 steps found)
• chloramphenicol biosynthesis (1/9 steps found)
• superpathway of candicidin biosynthesis (2/11 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.85

Use Curated BLAST to search for 2.6.1.85

Sequence Analysis Tools

See Q8EEY8 at UniProt or InterPro

Protein Sequence (467 amino acids)

>SO2221 para-aminobenzoate synthase, component I (NCBI ptt file) (Shewanella oneidensis MR-1)
MVNRASKQLASRQLDWTLSTADLFEHFAAEPWAILLDSANAPHLDAKFDIICVNPIATLI
THGELTEIKVQLPELTIPTQMSATDDPFTLVNQLLRHWYPQSFACELPFSGGAMGSFSYD
LGRRVEAIPNIAAQDIQLGEMNIGFYDWALIFDYQQQCWHLVHYLGETALETQLKIIEAK
MAKTVKIAEFTLVTPWAAQLKKADYVKKFNQVQAYLHSGDCYQINLTQRFEAQYQGDEWS
AYCKLRSANQAPFSAFMRLNDNTILSISPERFIQLRGDDIQTKPIKGTLPRHNDPALDKQ
AAQILANSPKDRAENVMIVDLLRNDIGKVAAPGSVQVPHLFAVESFPAVHHLVSTVTAKL
DPQYQACDLLRAAFPGGSITGAPKIRAMEIIEELEPSRRSLYCGSIGYISQDGQMDTSIT
IRTIVAERGKLYCWAGGGIVADSDVDAEYQESFDKVSRILPLLENQR