Protein Info for SO2089 in Shewanella oneidensis MR-1

Name: hypA
Annotation: hydrogenase expression/formation protein HypA (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 118 PF01155: HypA" amino acids 1 to 112 (112 residues), 104.5 bits, see alignment E=1.7e-34 TIGR00100: hydrogenase nickel insertion protein HypA" amino acids 1 to 114 (114 residues), 93.4 bits, see alignment E=5e-31

Best Hits

Swiss-Prot: 100% identical to HYPA_SHEON: Hydrogenase maturation factor HypA (hypA) from Shewanella oneidensis (strain MR-1)

KEGG orthology group: K04651, hydrogenase nickel incorporation protein HypA (inferred from 100% identity to son:SO_2089)

Predicted SEED Role

"[NiFe] hydrogenase nickel incorporation protein HypA" in subsystem NiFe hydrogenase maturation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EF96 at UniProt or InterPro

Protein Sequence (118 amino acids)

>SO2089 hydrogenase expression/formation protein HypA (NCBI ptt file) (Shewanella oneidensis MR-1)
MHEYSIVSALIEQCEQYAKANQATKVTRVEIKLGVMSGVEPALLQTAFETFKLDGICREA
KLCMTLQPLVIKCADCQQESVLDERSIVCPACNSYHTRVLDGEEMLLMQLEMEQAEDA