Protein Info for SO2020 in Shewanella oneidensis MR-1

Name: gsk
Annotation: inosine-guanosine kinase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.

Best Hits

Swiss-Prot: 69% identical to INGK_ECO57: Inosine-guanosine kinase (gsk) from Escherichia coli O157:H7

KEGG orthology group: K00892, inosine kinase [EC: 2.7.1.73] (inferred from 100% identity to son:SO_2020)

MetaCyc: 69% identical to inosine/guanosine kinase (Escherichia coli K-12 substr. MG1655)
Inosine kinase. [EC: 2.7.1.73]; 2.7.1.73 [EC: 2.7.1.73]

Predicted SEED Role

"Inosine-guanosine kinase (EC 2.7.1.73)" in subsystem Purine conversions (EC 2.7.1.73)

MetaCyc Pathways

adenine and adenosine salvage V (3/3 steps found)
superpathway of guanine and guanosine salvage (3/3 steps found)
guanine and guanosine salvage III (1/1 steps found)

KEGG Metabolic Maps

Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.73

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EFF3 at UniProt or InterPro

Protein Sequence (434 amino acids)

>SO2020 inosine-guanosine kinase (NCBI ptt file) (Shewanella oneidensis MR-1)
MKFPGQRKSKHYFPVKTRDPLLEQLTQQPQPFATYISGIDQTLVDIEAKVEDELLSRYGL
PKGNSTLINDEQAHTLYTELKQNGLISDEFAGGTIGNTVHNYSILADDRSVLFGVMSQNI
EVGSYAYRYLCNTSSKVDLNYLQPVDGPIGRCFTLISDCGERTFAISKGAMDKLTPEYID
KDIVQGSSALVLTAYLMRASGGDRITDAAMCAIEYAKAAEVPVVLTLGTRFLIEEDPIWW
QNFIKEHVTILAMNEDEGEALTGFRDPLLASEKALEWCDMVLTTAGPIGLYTAGYTDDAE
KRETSHTLLPGAIPEFNRYEFSRPKLKSDCENPIKVYAHISPYMGGPEKIGNTNGAGDGA
LSALLHDLAANTFHKTNVPGSSKHKRDGLCYSSFSQICKYANRVAYEVLAQHSPRLSRGL
PEREDSLEESYWER