Protein Info for SO1897 in Shewanella oneidensis MR-1

Name: ivd
Annotation: isovaleryl-CoA dehydrogenase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 389 PF02771: Acyl-CoA_dh_N" amino acids 14 to 125 (112 residues), 139.9 bits, see alignment E=8.8e-45 PF02770: Acyl-CoA_dh_M" amino acids 129 to 224 (96 residues), 89.5 bits, see alignment E=2.7e-29 PF00441: Acyl-CoA_dh_1" amino acids 236 to 384 (149 residues), 146.6 bits, see alignment E=1.3e-46 PF08028: Acyl-CoA_dh_2" amino acids 257 to 367 (111 residues), 50.1 bits, see alignment E=7.3e-17

Best Hits

Swiss-Prot: 64% identical to IVD_ORYSJ: Isovaleryl-CoA dehydrogenase, mitochondrial (Os05g0125500) from Oryza sativa subsp. japonica

KEGG orthology group: K00253, isovaleryl-CoA dehydrogenase [EC: 1.3.99.10] (inferred from 100% identity to son:SO_1897)

MetaCyc: 78% identical to isovaleryl-CoA dehydrogenase subunit (Pseudomonas aeruginosa PAO1)
RXN0-2301 [EC: 1.3.8.4]

Predicted SEED Role

"Isovaleryl-CoA dehydrogenase (EC 1.3.8.4)" (EC 1.3.8.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.8.4 or 1.3.99.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EFR9 at UniProt or InterPro

Protein Sequence (389 amino acids)

>SO1897 isovaleryl-CoA dehydrogenase (NCBI ptt file) (Shewanella oneidensis MR-1)
MNSLYTSLNFGLGEDVDMLRDAVHDFAQHEIAPIAAKVDHDNAFPNEIWPVLGGMGLLGV
TVPEEYGGANMGYLAHVVAMEEISRASASIGLSYGAHSNLCVNQINRNGNAAQKAKYLPK
LVSGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNKMWITNGPDANTYVIYAKTD
LTKGAHGITAFIVERGFKGFSQAQKLDKLGMRGSNTCELVFEDVEVPEENILGGLNNGVK
VLMSGLDYERVVLSGGPLGIMNACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMN
AAKAYVYSVAKSCDRGETTRKDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLL
RDAKLYEIGAGTSEIRRMLIGRELYNESK