Protein Info for SO1421 in Shewanella oneidensis MR-1

Name: ifcA-1
Annotation: fumarate reductase flavoprotein subunit (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 589 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF14537: Cytochrom_c3_2" amino acids 28 to 106 (79 residues), 63.6 bits, see alignment E=6.8e-21 PF07992: Pyr_redox_2" amino acids 149 to 341 (193 residues), 30.8 bits, see alignment E=7.2e-11 TIGR01813: flavocytochrome c" amino acids 149 to 582 (434 residues), 593.2 bits, see alignment E=1.5e-182 PF12831: FAD_oxidored" amino acids 149 to 336 (188 residues), 28.4 bits, see alignment E=3.8e-10 PF01266: DAO" amino acids 150 to 345 (196 residues), 49.4 bits, see alignment E=1.8e-16 PF00890: FAD_binding_2" amino acids 150 to 569 (420 residues), 269.8 bits, see alignment E=1.9e-83 PF13450: NAD_binding_8" amino acids 152 to 187 (36 residues), 29.5 bits, see alignment 2.5e-10

Best Hits

KEGG orthology group: K00244, fumarate reductase flavoprotein subunit [EC: 1.3.99.1] (inferred from 100% identity to son:SO_1421)

Predicted SEED Role

"Fumarate reductase flavoprotein subunit (EC 1.3.99.1)" in subsystem Succinate dehydrogenase (EC 1.3.99.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.1

Use Curated BLAST to search for 1.3.99.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EH10 at UniProt or InterPro

Protein Sequence (589 amino acids)

>SO1421 fumarate reductase flavoprotein subunit (NCBI ptt file) (Shewanella oneidensis MR-1)
MLNTKLLPLAMSAFFISTFSYGQSLSEFHIDKGNNCQTCHTKPIKVDDAENHENKSCESC
HGTMGELAAKSKSKLSPHHSHLIDVSCTSCHSGHKQPVFVCQTCHDSFKNEFKIPFSNDK
PVLDNYQFPEVTQEMIETALAKAPLEQHQVIVIGAGAAGHAAAISARQHGVADVVILEKQ
PYIGGNSMLAAGGMSAAETVTQALKHYPDSKALWYEDTMKGGHNINNPDLVKILTENGSA
GVDWLQAMGADLTSASSAGGHNAERLHRPTGGAKSGPEIVNTLKETAQKLGVETRTNSKV
IQLVQNKQGVITGVLVQGKHSKLHILGAKAVIIASGGFARNNELVAKYRPDLKGVDATNN
PGNVGDALTFAPKVGADIVDVKEIQAFPTAAAGKMVISGTARGAGAIMLNNDGERFCDEM
GPRDKVSECIWAQKGKDAWLVFDETVLDRLGQLRGMLDLGIIFKGNSADEMAKATKMNAQ
KFDQAIKRYNDFKVKGKDADFARKNMADDLQYPIYAVKIKPAVHHTMGGLKINTKTEVID
QNGLPIKGLFAAGEVTGGVHGANRLAGNAIADTIVFGRIAGEQVANSIK