Protein Info for SO1261 in Shewanella oneidensis MR-1

Annotation: mercaptopyruvate sulfurtransferase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00581: Rhodanese
  • amino acids 7 to 126 (120 residues), 40.6 bits, E=1.5e-14
  • amino acids 164 to 276 (113 residues), 39.2 bits, E=4.2e-14

Best Hits

KEGG orthology group: K01011, thiosulfate/3-mercaptopyruvate sulfurtransferase [EC: 2.8.1.1 2.8.1.2] (inferred from 100% identity to son:SO_1261)

Predicted SEED Role

"3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2)" (EC 2.8.1.2)

MetaCyc Pathways

• L-cysteine degradation III (2/2 steps found)
• thiosulfate disproportionation IV (rhodanese) (1/1 steps found)
• sulfide oxidation IV (mitochondria) (2/5 steps found)

KEGG Metabolic Maps

• Cysteine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.8.1.1

Use Curated BLAST to search for 2.8.1.1 or 2.8.1.2

Sequence Analysis Tools

See Q8EHG0 at UniProt or InterPro

Protein Sequence (285 amino acids)

>SO1261 mercaptopyruvate sulfurtransferase (NCBI ptt file) (Shewanella oneidensis MR-1)
MEYPLVSTQWLEEQLTSPELVLLDASMAVVLGKEPILYHEPICIPRSRRFDVEEDFCDKT
STQIHALPRFESFVEGIAKLGIEPQSLIVIYDNQGIYSSPRAWWIFKVMGFHRVYVLDGG
LPQWIAEDRVTSSRYQEEGIDYGVTDSAPLAAVLQYQSAKVMDAEAVLARLDDSESAIID
ARGATRFLGQVSEPRPGVRSGHIPHSVNLPFGEVLNGYKMKSTTELQAIFQALVGNKALR
IFSCGSGITACILILASVVAGHKSAVLYDGSWADWGSRTDLPIER