Protein Info for SO0935 in Shewanella oneidensis MR-1

Name: nhaD
Annotation: Na+/H+ antiporter (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 476 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 29 to 51 (23 residues), see Phobius details amino acids 63 to 80 (18 residues), see Phobius details amino acids 95 to 114 (20 residues), see Phobius details amino acids 127 to 149 (23 residues), see Phobius details amino acids 155 to 171 (17 residues), see Phobius details amino acids 176 to 197 (22 residues), see Phobius details amino acids 217 to 238 (22 residues), see Phobius details amino acids 259 to 276 (18 residues), see Phobius details amino acids 282 to 299 (18 residues), see Phobius details amino acids 346 to 367 (22 residues), see Phobius details amino acids 379 to 402 (24 residues), see Phobius details amino acids 413 to 438 (26 residues), see Phobius details amino acids 452 to 472 (21 residues), see Phobius details PF03600: CitMHS" amino acids 46 to 421 (376 residues), 118.7 bits, see alignment E=1.5e-38

Best Hits

Swiss-Prot: 65% identical to NHAD_ALKAM: Na(+)/H(+) antiporter NhaD (nhaD) from Alkalimonas amylolytica

KEGG orthology group: None (inferred from 100% identity to son:SO_0935)

Predicted SEED Role

"Na+/H+ antiporter NhaD type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EIA8 at UniProt or InterPro

Protein Sequence (476 amino acids)

>SO0935 Na+/H+ antiporter (NCBI ptt file) (Shewanella oneidensis MR-1)
MLSLCCVAILSGFSPAVWAMTEGGERLDLTAATVGYIAVCVFVLAYLLVMAEETLHLRKS
KPVLVAAGIIWGMIGFVYVQNGMSEVSETAFKHNLLEYAELLLFLLVAMTYINAMEERNL
FDAIRGWLVGRGFSLRTVFWLTGFMAFFISPVADNLTTALLMCAVVMKVGAGQRKFITLA
CINIVVAANAGGTFSPFGDITTLMVWQKGLVHFADFFYLFIPALVNFALPAAIMSIFIPH
YVPQPEKEQVYTKPGAKRIVALFLLTIATAVCAHSFLGMPPVLGMMTGLGFLQFFGYYLR
KTFDRSVARERAKAELRQDEQRLLQLGSVVPFDVFSRISRAEWDTLLFFYGVVLCVGGLG
FMGYLSLVSEALYSNWDATYANVAIGLLSSVVDNIPVMFAVLTMNPEMALGQWLLVTLTA
GVGGSLLSIGSAAGVALMGQARGIYTFGAHLRWTPVIALGYVASILVHMWLNAAMF