Protein Info for SO0840 in Shewanella oneidensis MR-1

Annotation: acetyl-CoA carboxylase multifunctional enzyme accADC, carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01039: Carboxyl_trans
  • amino acids 119 to 211 (93 residues), 40.8 bits, 4.1e-14
• PF03255: ACCA
  • amino acids 133 to 295 (163 residues), 93.2 bits, E=6.3e-30
• PF00289: Biotin_carb_N
  • amino acids 940 to 1051 (112 residues), 105.1 bits, 1e-33
• PF02786: CPSase_L_D2
  • amino acids 1057 to 1265 (209 residues), 198.7 bits, E=3e-62
• PF02222: ATP-grasp
  • amino acids 1078 to 1234 (157 residues), 40.5 bits, E=8.2e-14
• PF02785: Biotin_carb_C
  • amino acids 1276 to 1388 (113 residues), 84.8 bits, 1.5e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to son:SO_0840)

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2) / Biotin carboxylase of acetyl-CoA carboxylase (EC 6.3.4.14) / Biotin carboxyl carrier protein of acetyl-CoA carboxylase" in subsystem Fatty Acid Biosynthesis FASII (EC 6.3.4.14, EC 6.4.1.2)

MetaCyc Pathways

• biotin-carboxyl carrier protein assembly (3/4 steps found)
• fatty acid biosynthesis initiation (type I) (1/3 steps found)
• propanoyl CoA degradation I (1/3 steps found)
• 2-oxobutanoate degradation I (1/4 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (5/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
• jadomycin biosynthesis (3/9 steps found)
• methylaspartate cycle (9/19 steps found)
• 3-hydroxypropanoate cycle (4/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (7/18 steps found)
• glyoxylate assimilation (3/13 steps found)
• superpathway of L-methionine salvage and degradation (4/16 steps found)
• superpathway of the 3-hydroxypropanoate cycle (4/18 steps found)
• superpathway of mycolate biosynthesis (21/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Pyruvate metabolism
• Tetracycline biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.14 or 6.4.1.2

Sequence Analysis Tools

See Q8EIJ9 at UniProt or InterPro

Protein Sequence (1517 amino acids)

>SO0840 acetyl-CoA carboxylase multifunctional enzyme accADC, carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase (NCBI ptt file) (Shewanella oneidensis MR-1)
MTSNNQPKHMTQAQTPDPLFLQAEHLAKDFSLFPKHSKQSLSEEIKGLLNDDAIQANLKD
LASLDVDGYVAKVIQPTQDKGRPGAKRIIADLKGRLITETHLGSFYSAEVELNFGSRTRR
IGFIAQERTTANGAWMPEHHYAACKAIRHFAELSMPIVYLIDTPGADAGEVANSQNQAHS
ISKAIAESANVDVPTVGIVIGAGYSGGAIPLAAANILLSLRDGIFNTIQPQGLQSIARKY
NLSWQECAKSVGVSPEELYTSGCIDGIIDFSPGDRDERQHNLRRAIISSIEAVERAAVNF
VRESKDLREHYDRSLARFLNPSKNLMALELNAELAVATSPTNHHNLFGSAYRYLRYLTLR
SRIHSISQEQYGRLSRVSVPEGDLLARIQQEQDRVFQAWLASPDKLVYDEDLNKLWANFI
AKRDEISTERNMLTRFILGEPKENYKKARKALLFNISWSLYHRWKSNAANNFKGLIQHLE
NLPKSVTQAKWPELNQLTVLDVVVNDELREDFIWQCHNILIFNSLYDNVVGSLASIAKEA
MMSKSLSRNSVNNLLHKSIDHALSTQDTANDKAKFYKWLKYFMGQSNRADLLVRVEQWKS
VGFPQLNDSLFVILTYFFERLLPEYFDSESDHSKYTGAINPVRIGRRKDFWNRLTMGYQD
LLIQKVLRDEKRTGKMTWENVIKQFFTHFDEINGDKMSANLLNFPGFRLSIEDALDKGIR
PCGLITGIADFKEKGQKVRVGLAVSNTAFQAGAFDMASAEKFSALLIECAKRKLPVVCFI
SSGGMQTKEGAAALFSMAVVNDRITRFIRDNELPVLMFGFGDCTGGAQASFVTHPLVQTY
YLSGTNMPFAGQMVVPAYLPSTSTLSNYLSKVPGAMAGLVHNPFSENLDNQLASIDPLMP
MPTAKINEVIINALSTLVVEAPAEEEEIVQNDPRKLMKPINKVLVHARGCTAVKLIRKAH
DNNINVVLVASDPDMTAVPADMLKESDKLVCLGGNTSDESYLNAYSVLKVAEYEQVDALH
PGIGFLSESPQFAALCVNNGVNFVGPSVHSMTTMGNKSNAIKTSQAQNVPVVPGSHGILT
NAEQAVNVASEIGYPVLLKAVQGGGGKGIQVVKRPEDMIGLFQKTATEAAAAFGNGDLYL
EKYVTSLRHIEVQLLRDKFGHAKVLGLRDCSVQRNNQKVVEESGSTMLPDELKKQVLAYT
RALGDATDYMGAGTVEFIYNLDANEVYFMEMNTRLQVEHPVTEATSGIDIVSAQFDIAAG
RSIEHLEPKEIGYAMEVRVTAEKAALDSHGVLQLIPNPGKITECVFPDHPDVEIISIAAP
GKEVSPYYDSLIAQVIMRGENREDVIAKLHAYLDSVVLKGIATNIPLLKLILSDGTFKEG
VYDTNYLPRFMAELDIPALIAEMEAAAETVGVDTESLRVGESNELKVLAQGAGIFYTSPA
PGEPDFVKEGDIVTAEQTLALTEAMKMFSQVNLAGFNRQGAVLYPEDKKYRIERILNSNG
QQVSQGDLLFVVSPVED