Protein Info for SO0817 in Shewanella oneidensis MR-1

Name: metR
Annotation: transcriptional activator protein MetR (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 301 PF00126: HTH_1" amino acids 4 to 62 (59 residues), 62.8 bits, see alignment E=2.4e-21 PF03466: LysR_substrate" amino acids 91 to 291 (201 residues), 128.4 bits, see alignment E=2.5e-41

Best Hits

KEGG orthology group: K03576, LysR family transcriptional regulator, regulator for metE and metH (inferred from 100% identity to son:SO_0817)

Predicted SEED Role

"Transcriptional activator MetR" in subsystem Methionine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EIM1 at UniProt or InterPro

Protein Sequence (301 amino acids)

>SO0817 transcriptional activator protein MetR (NCBI ptt file) (Shewanella oneidensis MR-1)
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQ
EGARLLHLAEEILPKVLETETDLKNGLETDTNQLRVGIECHSCFRWLMPVMEQFRQDHPQ
AELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQHLFDFEVKLVVAKDHPLAKEA
YVTPKQLSRLPIISYPVPLARLDIYRHFLEPAGIEAGEQKTCDLTMMLLQRIACKDGIAA
LPNWSINEGHGLSLAAVKLGQEGLKRPLFGAYRRHSANSALVQNWLQLVASEGLTRQQKS
N