Protein Info for SO0558 in Shewanella oneidensis MR-1

Name: smtA
Annotation: smtA protein (NCBI ptt file)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 260 PF13489: Methyltransf_23" amino acids 30 to 205 (176 residues), 49.4 bits, see alignment E=1.3e-16 PF01209: Ubie_methyltran" amino acids 30 to 153 (124 residues), 29.7 bits, see alignment E=1.2e-10 PF13847: Methyltransf_31" amino acids 43 to 155 (113 residues), 51.5 bits, see alignment E=2.6e-17 PF13649: Methyltransf_25" amino acids 48 to 143 (96 residues), 60.6 bits, see alignment E=6.1e-20 PF08242: Methyltransf_12" amino acids 49 to 145 (97 residues), 58.7 bits, see alignment E=2.4e-19 PF08241: Methyltransf_11" amino acids 49 to 146 (98 residues), 65.5 bits, see alignment E=1.7e-21

Best Hits

Swiss-Prot: 45% identical to CMOM_ECO57: tRNA 5-carboxymethoxyuridine methyltransferase (cmoM) from Escherichia coli O157:H7

KEGG orthology group: K06219, S-adenosylmethionine-dependent methyltransferase (inferred from 100% identity to son:SO_0558)

MetaCyc: 45% identical to tRNA cmo5U34 methyltransferase (Escherichia coli K-12 substr. MG1655)
2.1.1.M28 [EC: 2.1.1.M28]

Predicted SEED Role

"S-adenosylmethionine-dependent methyltransferase Functionally Coupled to the MukBEF Chromosome Partitioning Mechanism" in subsystem MukBEF Chromosome Condensation

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.M28

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8EJA9 at UniProt or InterPro

Protein Sequence (260 amino acids)

>SO0558 smtA protein (NCBI ptt file) (Shewanella oneidensis MR-1)
MQDKNFDKLAQKFAKNIYGTPKGEIRAAVLWRDLAPALAQFGDKKLRILDAGGGFGYFSQ
KLARLGHEVVLCDISAEMLAQAKEQIDASDTPLAIRLVHAPIQALSITEHGMFDLILCHA
VVEWLADAKTTMEGLLTMLKPNGLFSLMFYNKEAMRFHALVSGNFDYVAADLKVKKKVRL
TPTHPLYIHEVKLWFAQWQMALLKESGVRVIHDYLKKQQAADFDYQKLLSMELEYSQREP
YISLGRYVHFLGQSTATHSE