Protein Info for Rru_A3700 in Rhodospirillum rubrum S1H

Annotation: Secretion protein HlyD (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 381 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 45 to 356 (312 residues), 312.6 bits, see alignment E=1.3e-97 PF25917: BSH_RND" amino acids 70 to 192 (123 residues), 47.7 bits, see alignment E=3.3e-16 PF25973: BSH_CzcB" amino acids 72 to 196 (125 residues), 33.4 bits, see alignment E=1e-11 PF25944: Beta-barrel_RND" amino acids 201 to 273 (73 residues), 38.3 bits, see alignment E=4.4e-13 PF25954: Beta-barrel_RND_2" amino acids 205 to 274 (70 residues), 56.7 bits, see alignment E=6.7e-19 PF25967: RND-MFP_C" amino acids 282 to 344 (63 residues), 39.9 bits, see alignment E=1e-13

Best Hits

Swiss-Prot: 34% identical to Y894_HAEIN: Uncharacterized protein HI_0894 (HI_0894) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A3700)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RN01 at UniProt or InterPro

Protein Sequence (381 amino acids)

>Rru_A3700 Secretion protein HlyD (NCBI) (Rhodospirillum rubrum S1H)
MKKKRLAIMLVGSVVLFGGVIGFTVFRDHMIAQYFANQPEPVITVTVEDARAEDWQDTIP
AVGTLRAINGVTVGAAVAGIVETISFESGQRVKKGDLLVRLDDGEERGELDAVRAQAELS
RITAGRARRLVQSAAGTRANLDDAEAQLRVNLATIGQLEARVAKKTVTAPFDGVLGVRAV
DLGEYVTAGQTLVDLQDLSVILADFSVSQKDLGRVAVGAKLTLTTDAWPGRAFEGTIKAI
APKVDANTGMAVVEGRFDNPDGALRPGMFAKLAVLRAERQSVVTVPATAVTYSLHGDALY
VLKEAGEDGKVRVDRITVTTGVRRGDRVVVTAGLSAGQRVVTSGQVKLNDGSAVAVAQAP
LNTAARAESGAKGDSTKDTLR