Protein Info for Rru_A3667 in Rhodospirillum rubrum S1H

Annotation: Short-chain dehydrogenase/reductase SDR (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 61% identical to YHDF_BACSU: Uncharacterized oxidoreductase YhdF (yhdF) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 100% identity to rru:Rru_A3667)

MetaCyc: 51% identical to aldehyde reductase (chloroplastic) (Arabidopsis thaliana col)
Aldehyde reductase. [EC: 1.1.1.21]; Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]

Predicted SEED Role

"oxidoreductase, short chain dehydrogenase/reductase family"

MetaCyc Pathways

glycerol degradation to butanol (12/16 steps found)
methylglyoxal degradation III (1/2 steps found)
pyruvate fermentation to butanol I (5/8 steps found)
D-arabinose degradation V (1/3 steps found)
superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (11/17 steps found)
superpathway of Clostridium acetobutylicum solventogenic fermentation (8/13 steps found)
superpathway of methylglyoxal degradation (4/8 steps found)
L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
detoxification of reactive carbonyls in chloroplasts (4/10 steps found)
traumatin and (Z)-3-hexen-1-yl acetate biosynthesis (3/12 steps found)
superpathway of lipoxygenase (4/22 steps found)
superpathway of pentose and pentitol degradation (9/42 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.2 or 1.1.1.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RN34 at UniProt or InterPro

Protein Sequence (284 amino acids)

>Rru_A3667 Short-chain dehydrogenase/reductase SDR (NCBI) (Rhodospirillum rubrum S1H)
MSDDVLQPPQDQDSQPGHELEMTPQPDCQPRHPGSDRLAGKVALISGGDSGIGRAVALAF
AREGAKIALLYLDEHDDARETERLVMAEGRECLVMPGDVGDEAICIDAVAQVIGNFGALD
ILVNNAAEQHEVEDLSDLTAGQLEKTFRTNVFGYIYLAKAALPHLPKGGSIINTTSITAY
QGHRTLIDYSATKGAIVALTRSLSQSLLDRGIRVNAVAPGPIWTPLIPASFSPDHVASHG
ASVPMGRAGQPNEVAPAYVFLASDDASYISGQVIHPNGGAIIGS