Protein Info for Rru_A3655 in Rhodospirillum rubrum S1H

Annotation: Phosphoribosylaminoimidazolecarboxamideformyltransferase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00355: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
  • amino acids 8 to 526 (519 residues), 695.2 bits, E=3e-213
• PF02142: MGS
  • amino acids 19 to 132 (114 residues), 83.4 bits, E=1.1e-27
• PF01808: AICARFT_IMPCHas
  • amino acids 138 to 450 (313 residues), 421.2 bits, E=3e-130

Best Hits

Swiss-Prot: 100% identical to PUR9_RHORT: Bifunctional purine biosynthesis protein PurH (purH) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K00602, phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC: 2.1.2.3 3.5.4.10] (inferred from 100% identity to rru:Rru_A3655)

Predicted SEED Role

"IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)" in subsystem De Novo Purine Biosynthesis (EC 2.1.2.3, EC 3.5.4.10)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• One carbon pool by folate
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.2.3 or 3.5.4.10

Sequence Analysis Tools

See Q2RN46 at UniProt or InterPro

Protein Sequence (526 amino acids)

>Rru_A3655 Phosphoribosylaminoimidazolecarboxamideformyltransferase (NCBI) (Rhodospirillum rubrum S1H)
MLHSLPIRRALISVSDKGGLVPFARFLADHDIEILSTGGSAKALADAGIPVTEVADFTGF
PEMLDGRVKTLHPKIHGGILGIRDNPEHQRAMAAHEILPIDLVVVNLYPFEATVAKGAAF
EDCVENIDIGGPALIRAAAKNHEAVTVVVDPEDYQPVMDAMTAEGGATTLELRRKLASAA
FARCGAYDGAISRWFQGQVGDETPRHIVFAGRLRQTLRYGENPHQKAAFYGHGIARPGVA
SAEQLQGKELSYNNINDTDAAFDLVCEFAEPAVAIIKHANPCGVAQGASVVEAYKAALAC
DPVSAFGGIVALNRPIDRDSAVEITKIFTEVVIAPDADAEARAIFAAKKNLRLLLTGVVA
DTTAPGLTVRSVAGGMLVQDRDAADLLSADLKVVSKRTPTERELADMLIAFKVCKHVKSN
AIVYVKDGATVGIGAGQMSRVDSARIASWKADEAAEAAGLAQSPTQGSVVASDAFFPFAD
GLLAAAKAGATAVIQPGGSMRDDEVIKAADEAGLAMVFTGLRHFRH