Protein Info for Rru_A3613 in Rhodospirillum rubrum S1H

Annotation: Quinate/Shikimate 5-dehydrogenase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00507: shikimate dehydrogenase
  • amino acids 8 to 275 (268 residues), 220.2 bits, E=1.5e-69
• PF08501: Shikimate_dh_N
  • amino acids 11 to 93 (83 residues), 90.4 bits, E=1.1e-29
• PF01488: Shikimate_DH
  • amino acids 129 to 172 (44 residues), 25.4 bits, 1.9e-09
• PF18317: SDH_C
  • amino acids 249 to 277 (29 residues), 29.1 bits, see alignment (E = 1e-10)

Best Hits

Swiss-Prot: 100% identical to AROE_RHORT: Shikimate dehydrogenase (NADP(+)) (aroE) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K00014, shikimate dehydrogenase [EC: 1.1.1.25] (inferred from 100% identity to rru:Rru_A3613)

Predicted SEED Role

"Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• superpathway of chorismate metabolism (37/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.25

Sequence Analysis Tools

See Q2RN88 at UniProt or InterPro

Protein Sequence (283 amino acids)

>Rru_A3613 Quinate/Shikimate 5-dehydrogenase (NCBI) (Rhodospirillum rubrum S1H)
MITGKARVAGVIGWPVGHSRSPRLHGFWLARHGIDGAYVPLAVAPEALERALAALPALGL
AGVNVTVPHKEHALARMDALTERARRIGAVNTIVCQSDGRLLGDNTDGFGFLENLRQRRP
DWRAGHGPAVVLGAGGAARAVCASLLEAGCPALTLVNRDQGRARALAEALAAWSPVPITL
ATWDEAPRTLGGAALLVNTTSLGMVGQPPLDLDLRGLAPSALVTDIVYAPLETPLLARAR
ALGLATVDGLGMLLHQGRPGFEAWFGVAPEVDDALRAAVLGKP