Protein Info for Rru_A3549 in Rhodospirillum rubrum S1H

Annotation: Cobyric acid synthase CobQ (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 516 PF01656: CbiA" amino acids 24 to 263 (240 residues), 69.9 bits, see alignment E=3.1e-23 TIGR00313: cobyric acid synthase CobQ" amino acids 24 to 510 (487 residues), 406.4 bits, see alignment E=9e-126 PF13500: AAA_26" amino acids 143 to 255 (113 residues), 38.1 bits, see alignment E=2.3e-13 PF07685: GATase_3" amino acids 279 to 469 (191 residues), 180.4 bits, see alignment E=5e-57

Best Hits

Swiss-Prot: 58% identical to COBQ_METPB: Cobyric acid synthase (cobQ) from Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)

KEGG orthology group: K02232, adenosylcobyric acid synthase [EC: 6.3.5.10] (inferred from 100% identity to rru:Rru_A3549)

Predicted SEED Role

"Cobyric acid synthase (EC 6.3.5.10)" (EC 6.3.5.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.5.10

Use Curated BLAST to search for 6.3.5.10

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RNF2 at UniProt or InterPro

Protein Sequence (516 amino acids)

>Rru_A3549 Cobyric acid synthase CobQ (NCBI) (Rhodospirillum rubrum S1H)
MTDPTAPIDFPALSPKAPRRAKALMIQGTSSDVGKSLLVAGLCRAYTRRGLSVRPFKAQN
MSNNAAVAADGDDDSTTKGEIGRAQALQARACKVAPSIHMNPVLLKPQTLIGAQVVLRGR
VLGNCPARQYHLMKPQLMPAVMDSFNRTAALADLVIVEGAGSNAEVYLRASDITNMKLAE
NADLPVVVVGDIDRGGALAAIVGTHALLTEDERARVVGYIINKFRGDLSLFEPACAVMTE
RTGWPWLGVVRWFESADRLPAEDALALERPAEGSGKGLRVAVPQLSRVANFDDIDPLAAE
PGVEVRWIRPGHPIPAETDVVILPGSKVTRADLDVLRREGWDIDILAHVRRGGRVVGLCA
GFQMLGKVVRDPEGIEGPPGETAGLGLLDIETVIGGEKRLVDIAVTDQRSGQPIRGYEMH
MGRTTGPGLERPWFLLDDGAGGPARREGAVSADGLVSGAYIHGLFGGDDFRSHWLTGLGA
AASGLDFEARTETALEALADHLEANLDLDALLAFAR