Protein Info for Rru_A3444 in Rhodospirillum rubrum S1H

Annotation: Adenosylhomocysteinase (NCBI)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 78% identical to SAHH_BRASB: Adenosylhomocysteinase (ahcY) from Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)

KEGG orthology group: K01251, adenosylhomocysteinase [EC: 3.3.1.1] (inferred from 100% identity to rru:Rru_A3444)

Predicted SEED Role

"Adenosylhomocysteinase (EC 3.3.1.1)" in subsystem Methionine Biosynthesis or Methionine Degradation (EC 3.3.1.1)

MetaCyc Pathways

S-adenosyl-L-methionine salvage II (3/3 steps found)
superpathway of L-cysteine biosynthesis (mammalian) (4/5 steps found)
L-methionine degradation I (to L-homocysteine) (2/3 steps found)
superpathway of L-methionine salvage and degradation (9/16 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.3.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2RNQ7 at UniProt or InterPro

Protein Sequence (467 amino acids)

>Rru_A3444 Adenosylhomocysteinase (NCBI) (Rhodospirillum rubrum S1H)
MSFTDYVVTDISLADWGRKEIDIAESEMPGLMATRAEYAKAQPLKGARVAGSLHMTIQTA
VLIETLVALGADVRWASCNIYSTQDHAAAAIAAAGIPVFARKGEGLEDYWDYTHKIFEWA
DGGTPNMILDDGGDATLLIHLGARAEKDASLLDNPTSEEEEVLYAAIKARLAAKPGWYST
VLAAIKGVTEETTTGVHRLYEMEKAGTLPFPAINVNDSVTKSKFDNKYGCRESLVDGIRR
ATDVMMAGKVAVVAGYGDVGKGSSESLRSSGCRVLVTEVDPICALQAAMEGFEVVTMEDA
APRGDIFVTTTGNIDVITLDHMRAMKDRAIVCNIGHFDNEIQVAALKNLTWNNVKPQVDE
ITFPDGHRIILLAQGRLVNLGCATGHPSFVMSASFTNQTLAQIELFANNADGKYANRVYV
LPKHLDEKVARLHLEKLGVRLSTLSPKQAAYIGVTPQGPFKGEAYRY